Advances in in vitro and in vivo bioreactor-based bone generation for craniofacial tissue engineering

E Watson, AG Mikos - BME frontiers, 2023 - spj.science.org
Craniofacial reconstruction requires robust bone of specified geometry for the repair to be
both functional and aesthetic. While native bone from elsewhere in the body can be …

[HTML][HTML] Computational fluid dynamics modeling of cell cultures in bioreactors and its potential for cultivated meat production—A mini-review

FJC Rivera, J Chen - Future Foods, 2022 - Elsevier
Cultivated meat production was developed as a response to the rapidly increasing demand
for meat consumption. Bioreactor designs were adapted from other bioprocesses to account …

Culturing 3D chitosan/gelatin/nano-hydroxyapatite and bone-derived scaffolds in a dynamic environment enhances osteochondral reconstruction

X Hu, Y Su, H Ma, J Zhu, YY Cheng, W Li… - International Journal of …, 2024 - Elsevier
Bioreactor can provide a dynamic culture environment for the in vitro construction of
osteochondral tissue engineering. They facilitate more efficient exchange of nutrients and …

[HTML][HTML] Translation of biophysical environment in bone into dynamic cell culture under flow for bone tissue engineering

S Yamada, PN Ockermann, T Schwarz… - Computational and …, 2023 - Elsevier
Bone is a dynamic environment where osteocytes, osteoblasts, and mesenchymal
stem/progenitor cells perceive mechanical cues and regulate bone metabolism accordingly …

Rational scaling-up strategy for cultured meat production based on bioreactor micro-environment evaluation

W Sun, H Tang, L Wang, G Du, J Zhou, J Chen, X Guan - Food Bioscience, 2025 - Elsevier
Cultured meat, an emerging technology in the alternative protein landscape, aims to provide
a sustainable and animal-friendly protein source to complement traditional meat production …

[HTML][HTML] New insights from locally resolved hydrodynamics in stirred cell culture reactors

F Freiberger, J Budde, E Ateş, M Schlüter, R Pörtner… - Processes, 2022 - mdpi.com
The link between hydrodynamics and biological process behavior of antibody-producing
mammalian cell cultures is still not fully understood. Common methods to describe …

Microwell‐based flow culture increases viability and restores drug response in prostate cancer spheroids

MC Payne, SY Ho, T Hashimoto… - Biotechnology …, 2023 - Wiley Online Library
Abstract 3D cancer spheroids represent a highly promising model for study of cancer
progression and therapeutic development. Wide‐scale adoption of cancer spheroids …

Hydrodynamics and mass transfer in spinner flasks: Implications for large scale cultured meat production

J Zhang, X Li, H Liu, J Zhou, J Chen, G Du - Biochemical Engineering …, 2021 - Elsevier
Cultured meat has emerged as a potential alternative source of animal proteins and fat.
Commercially viable cultured meat production likely requires proliferation bioreactors much …

Characterization of the dynamic viscosity of cell cultures and its effect on mixing performance in a spinner flask bioreactor

F Cantarero-Rivera, DH D'Souza, M Dhar… - Biochemical Engineering …, 2024 - Elsevier
Computational fluid dynamics (CFD) models have been developed to simulate cell culturing
bioreactors but assume water-like viscosity properties due to significant data gaps. This …

Characterization of the Aeration and Hydrodynamics in Vertical-Wheel Bioreactors

PM Neto, DES Nogueira, Y Hashimura, S Jung… - Bioengineering, 2022 - mdpi.com
In this work, the oxygen transport and hydrodynamic flow of the PBS Vertical-Wheel MINI™
0.1 bioreactor were characterized using experimental data and computational fluid …