Regulation, functions and transmission of bivalent chromatin during mammalian development
TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
Epigenetic balance of gene expression by Polycomb and COMPASS families
A Piunti, A Shilatifard - Science, 2016 - science.org
BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …
expression to direct embryonic development and to maintain tissue homeostasis through …
Th2 cells in health and disease
T Nakayama, K Hirahara, A Onodera… - Annual review of …, 2017 - annualreviews.org
Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2
cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection …
cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection …
PRC1 catalytic activity is central to polycomb system function
The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …
expression. Despite being extensively studied, how the Polycomb system selects its target …
[HTML][HTML] Polycomb repressive complex 1 generates discrete compacted domains that change during differentiation
Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent
misexpression during differentiation and development. Some PcG proteins covalently modify …
misexpression during differentiation and development. Some PcG proteins covalently modify …
PRC2 is high maintenance
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive …
regulation during development. Recent studies suggest that Polycomb repressive …
Two distinct modes for propagation of histone PTMs across the cell cycle
C Alabert, TK Barth, N Reverón-Gómez… - Genes & …, 2015 - genesdev.cshlp.org
Epigenetic states defined by chromatin can be maintained through mitotic cell division.
However, it remains unknown how histone-based information is transmitted. Here we …
However, it remains unknown how histone-based information is transmitted. Here we …
RNA polymerase II associates with active genes during DNA replication
TK Fenstermaker, S Petruk, SK Kovermann, HW Brock… - Nature, 2023 - nature.com
The transcriptional machinery is thought to dissociate from DNA during replication. Certain
proteins, termed epigenetic marks, must be transferred from parent to daughter DNA strands …
proteins, termed epigenetic marks, must be transferred from parent to daughter DNA strands …
Phase-separated transcriptional condensates accelerate target-search process revealed by live-cell single-molecule imaging
Compartmentalization by liquid-liquid phase separation is implicated in transcription. It
remains unclear whether and how transcriptional condensates accelerate the search of …
remains unclear whether and how transcriptional condensates accelerate the search of …