Gene therapy targeting p53 and KRAS for colorectal cancer treatment: a myth or the way forward?

HH Hasbullah, M Musa - International journal of molecular sciences, 2021 - mdpi.com
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy worldwide and
is responsible as one of the main causes of mortality in both men and women. Despite …

[HTML][HTML] Ethical issues related to research on genome editing in human embryos

E Niemiec, HC Howard - Computational and structural biotechnology …, 2020 - Elsevier
Although the potential advantages of clinical germline genome editing (GGE) over currently
available methods are limited, the implementation of GGE in the clinic has been proposed …

[图书][B] The basics of bioethics

RM Veatch - 2016 - taylorfrancis.com
The third edition of The Basics of Bioethics continues to provide a balanced and systematic
ethical framework to help students analyze a wide range of controversial topics in medicine …

Do CRISPR germline ethics statements cut it?

C Brokowski - The CRISPR journal, 2018 - liebertpub.com
The extraordinary wave of genomic-engineering innovation, driven by CRISPR-Cas9, has
sparked worldwide scientific and ethical uncertainty. Great concern has arisen across the …

Antisense therapies in neurological diseases

JB Brunet de Courssou, A Durr, D Adams, JC Corvol… - Brain, 2022 - academic.oup.com
Advances in targeted regulation of gene expression allowed new therapeutic approaches
for monogenic neurological diseases. Molecular diagnosis has paved the way to …

CRISPR/Cas gene editing in the human germline

B Bekaert, A Boel, G Cosemans, L De Witte… - Seminars in cell & …, 2022 - Elsevier
The ease and efficacy of CRISPR/Cas9 germline gene editing in animal models paved the
way to human germline gene editing (HGGE), by which permanent changes can be …

Attitudes of members of genetics professional societies toward human gene editing

AJ Armsby, Y Bombard, NA Garrison… - The CRISPR …, 2019 - liebertpub.com
Gene-editing technologies have improved in ease, efficiency, and precision. Although
discussions are occurring around acceptable uses of human gene editing, limited data exist …

Beginning of life ethics at the dawn of a new era of genome editing: are bioethical precepts and fast-evolving biotechnologies irreconcilable?

S Marinelli, A Del Rio - La Clinica Terapeutica, 2020 - iris.uniroma1.it
The amazing and almost unimaginable advances that have unfolded over the past decades
in biotechnologies (heritable germline editing in particular) have brought bioethical issues to …

The view from the benches: Scientists' perspectives on the uses and governance of human gene-editing research

M Waltz, ET Juengst, T Edwards… - The CRISPR …, 2021 - liebertpub.com
The advent of human gene editing has stimulated international interest in how best to
govern this research. However, research on stakeholder views has neglected scientists …

Ethics and genomic editing using the crispr-cas9 technique: Challenges and conflicts

D Lorenzo, M Esquerda, F Palau, FJ Cambra - Nanoethics, 2022 - Springer
The field of genetics has seen major advances in recent decades, particularly in research,
prevention and diagnosis. One of the most recent developments, the genomic editing …