Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

O Palomares, M Akdis, M Martín‐Fontecha… - Immunological …, 2017 - Wiley Online Library
Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …

A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2

C Riggioni, P Comberiati, M Giovannini, I Agache… - Allergy, 2020 - Wiley Online Library
Abstract In December 2019, China reported the first cases of the coronavirus disease 2019
(COVID‐19). This disease, caused by the severe acute respiratory syndrome–related …

Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens

CA Akdis, M Akdis - World Allergy Organization Journal, 2015 - Springer
Substantial progress in understanding mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumors, organ transplantation and chronic infections has led to a …

Suppression of innate inflammation and immunity by interleukin‐37

CA Dinarello, C Nold‐Petry, M Nold… - European journal of …, 2016 - Wiley Online Library
IL‐37 is unique in the IL‐1 family in that unlike other members of the family, IL‐37 broadly
suppresses innate immunity. IL‐37 can be elevated in humans with inflammatory and …

Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values

RR Jansen, J Wieringa, SM Koekkoek… - Journal of clinical …, 2011 - Am Soc Microbiol
Highly sensitive techniques, such as PCR, have greatly improved the detection of respiratory
viruses. However, the sensitivity of PCR tests also complicates clinical interpretation, as the …

Regulatory T cells and immunoglobulin E: a new therapeutic link for autoimmunity?

O Palomares, D Elewaut, PM Irving, X Jaumont… - Allergy, 2022 - Wiley Online Library
Autoimmune diseases have a prevalence of approximately 7 to 9% and are classified as
either organ‐specific diseases, including type I diabetes, multiple sclerosis, inflammatory …

The pathogens profile in children with otitis media with effusion and adenoid hypertrophy

GP Buzatto, E Tamashiro, JL Proenca-Modena… - PLoS …, 2017 - journals.plos.org
Objectives To evaluate the presence of viruses and bacteria in middle ear and adenoids of
patients with and without otitis media with effusion (OME). Methods Adenoid samples and …

The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response

V Elenius, O Palomares, M Waris, R Turunen… - PloS one, 2017 - journals.plos.org
Background Tonsils have an active role in immune defence and inducing and maintaining
tolerance to allergens. Vitamins A, D, and E, and antimicrobial peptide LL-37 may have …

The ubiquity of asymptomatic respiratory viral infections in the tonsils and adenoids of children and their impact on airway obstruction

H Faden, V Callanan, M Pizzuto, M Nagy… - International Journal of …, 2016 - Elsevier
Background Airway obstruction due to enlargement of tonsils and adenoids is a common
pediatric problem resulting in sleep disordered breathing. The cause for the relatively …

Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis

K Geißler, R Markwart, RP Requardt, C Weigel… - Plos one, 2017 - journals.plos.org
The palatine tonsils, localized in the oropharynx, are easily accessible secondary lymphoid
tissue in humans. Inflammation of the palatine tonsils, local and chronic in case of chronic …