Our understanding of genes that cause skeletal muscle disease has increased
tremendously over the past three decades. Advances in approaches to genetics and …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty
in older persons, but the molecular mechanisms of such decline are not understood. Here …

In recent years, our view of the nucleus has changed considerably with an increased
awareness of the roles dynamic higher order chromatin structure and nuclear organization …

Background Residual feed intake (RFI), a measure of feed efficiency, is the difference
between observed feed intake and the expected feed requirement predicted from growth …

We identified a member of the BTB/Kelch protein family that is mutated in nemaline
myopathy type 6 (NEM6), an autosomal-dominant neuromuscular disorder characterized by …

Human hallmarks of sarcopenia include muscle weakness and a blunted response to
exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and …

Background Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked
to contraction of an array of tandem 3.3-kb repeats (D4Z4) at 4q35. Within each repeat unit is …

Simple Summary Skeletal muscle is an important tissue and its development is strictly
regulated by genes. In this study, in order to understand the muscle-related gene expression …

Numerous computational methods based on sequences or structures have been developed
for the characterization of protein function, but they are still unsatisfactory to deal with the …