Genetics of circadian rhythms and sleep in human health and disease

JM Lane, J Qian, E Mignot, S Redline… - Nature Reviews …, 2023 - nature.com
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

The translational neuroscience of sleep: a contextual framework

MA Grandner, FX Fernandez - Science, 2021 - science.org
Sleep is entwined across many physiologic processes in the brain and periphery, thereby
exerting tremendous influence on our well-being. Yet sleep exists in a social-environmental …

Sleep and the hypothalamus

AR Adamantidis, L de Lecea - Science, 2023 - science.org
Neural substrates of wakefulness, rapid eye movement sleep (REMS), and non-REMS
(NREMS) in the mammalian hypothalamus overlap both anatomically and functionally with …

Genetics of the human circadian clock and sleep homeostat

LH Ashbrook, AD Krystal, YH Fu… - …, 2020 - nature.com
Timing and duration of sleep are controlled by the circadian system, which keeps an~ 24-h
internal rhythm that entrains to environmental stimuli, and the sleep homeostat, which rises …

Associations of short sleep duration with appetite‐regulating hormones and adipokines: A systematic review and meta‐analysis

J Lin, Y Jiang, G Wang, M Meng, Q Zhu, H Mei… - Obesity …, 2020 - Wiley Online Library
In the current study, a systematic review and meta‐analysis were conducted to summarize
and assess whether short sleep duration is associated with appetite‐regulating hormones …

Connecting insufficient sleep and insomnia with metabolic dysfunction

D Duan, LJ Kim, JC Jun… - Annals of the new York …, 2023 - Wiley Online Library
The global epidemic of obesity and type 2 diabetes parallels the rampant state of sleep
deprivation in our society. Epidemiological studies consistently show an association …

Shank3 modulates sleep and expression of circadian transcription factors

AM Ingiosi, H Schoch, T Wintler, KG Singletary… - Elife, 2019 - elifesciences.org
Autism Spectrum Disorder (ASD) is the most prevalent neurodevelopmental disorder in the
United States and often co-presents with sleep problems. Sleep problems in ASD predict the …

Circadian regulation of metabolism: commitment to health and diseases

T Sato, S Sato - Endocrinology, 2023 - academic.oup.com
The circadian clock is a biological timekeeping system to govern temporal rhythms of the
endocrine system and metabolism. The master pacemaker of biological rhythms is housed …

Neurogenetic basis for circadian regulation of metabolism by the hypothalamus

J Cedernaes, N Waldeck, J Bass - Genes & Development, 2019 - genesdev.cshlp.org
Circadian rhythms are driven by a transcription–translation feedback loop that separates
anabolic and catabolic processes across the Earth's 24-h light–dark cycle. Central …

The neurobiological basis of sleep and sleep disorders

WJ Joiner - Physiology, 2018 - journals.physiology.org
The functions of sleep remain a mystery. Yet they must be important since sleep is highly
conserved, and its chronic disruption is associated with various metabolic, psychiatric, and …