Over the past decade, RNA sequencing (RNA-seq) has become an indispensable tool for
transcriptome-wide analysis of differential gene expression and differential splicing of …

While traditional approaches for disease management in the era of modern medicine have
saved countless lives and enhanced patient well‐being, it is clear that there is significant …

Immune-checkpoint blockade is able to achieve durable responses in a subset of patients;
however, we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4 …

Immunotherapies have achieved remarkable successes in the treatment of cancer, but major
challenges remain,. An inherent weakness of current treatment approaches is that …

Immunotargeting of tumor-specific antigens is a powerful therapeutic strategy.
Immunotherapies directed at MHC-I complexes have expanded the scope of antigens and …

Mass cytometry has revolutionized immunophenotyping, particularly in exploratory settings
where simultaneous breadth and depth of characterization of immune populations is needed …

Cancer cells can inhibit effector T cells (Teff) through both immunomodulatory receptors and
the impact of cancer metabolism on the tumor microenvironment. Indeed, Teff require high …

Advances in single-cell mass cytometry have increasingly improved highly multidimensional
characterization of immune cell heterogeneity. The immunoassay multiplexing capacity …

Modern single-cell technologies allow multiplexed sampling of cellular states within a tissue.
However, computational tools that can infer developmental cell-state transitions reproducibly …

Immune checkpoint inhibitor therapy has changed clinical practice for patients with different
cancers, since these agents have demonstrated a significant improvement of overall survival …