Simple Summary A subset of colorectal cancers (CRCs) is characterized by a mismatch
repair deficiency that is frequently associated with microsatellite instability (MSI). The …

The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this
review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming …

The early onset of colorectal cancer (CRC) in individuals younger than 50 years is an
emerging phenomenon, and obesity is a strong risk factor. Inflammatory mechanisms are …

The gut microbiome is widely analyzed using high-throughput sequencing, such as 16S
rRNA gene amplicon sequencing and shotgun metagenomic sequencing (SMS). DNA …

Despite a decrease in the prevalence of colorectal cancer (CRC) over the last 40 y, the
prevalence of CRC in people under 50 y old is increasing around the globe. Early onset (≤ …

Colorectal cancer (CRC) is one of the most common cancers and is the second leading
cause of cancer-related death in the world. Due to the westernization of diets, young patients …

Background Early-onset pancreatic cancer (EOPC), defined as age≤ 45 years at diagnosis,
accounts for 3% of all pancreatic cancer cases. Although differences in tumor biology have …

Simple Summary Colorectal cancer (CRC) is the third most common malignancy in the world
and is the second most common cancer in Saudi Arabia. The faecal-associated microbiota …

Epithelial adherens junctions (AJs) are cell-cell adhesion complexes that are influenced by
tissue mechanics, such as those emanating from the extracellular matrix (ECM). Here, we …

Introduction: Metastatic colorectal cancer (mCRC) is characterised by multiple treatment
strategies. Randomised clinical trials are not always aligned with clinical practice, and …