The use of alkyl chlorides as C (sp 3)-hybridized electrophiles for the construction of C (sp 3)–
C (sp 3) bonds represents one of the most challenging issues in organic synthesis …

Each year, new drugs are introduced to the market, representing structures that have affinity
for biological targets implicated in human diseases and conditions. These new chemical …

Carbenes are highly enabling reactive intermediates that facilitate a diverse range of
otherwise inaccessible chemistry, including small-ring formation and insertion into strong σ …

Simmons–Smith cyclopropanation is a widely used reaction in organic synthesis for
stereospecific conversion of alkenes into cyclopropane. The utility of this reaction can be …

Cyclopropanes are common building blocks in pharmaceuticals, agrochemicals, and
organic materials. The most general methods for the synthesis of chiral cyclopropanes are …

Deoxygenative difunctionalization of carbonyls affords a straightforward and effective route
to construct geminal dual functionalized motifs. However, the research in this field is very …

Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months | ACS
Central Science ACS ACS Publications C&EN CAS Find my institution Log In ACS Central …

The synthesis of dialkyl-substituted cyclopropanes is an important challenge in synthesis
with applications in drug discovery and agrochemistry. Herein, we report on the synthesis of …

Small molecules containing 1, 1-dimethylcyclopropanes are prevalent throughout nature but
are difficult to synthesize using state-of-the-art metal-catalyzed carbene transfer methods …

Cyclopropanes are ubiquitous in medicines, yet robust synthetic access to a wide range of
sterically and electronically diverse analogs remains a challenge. To address the synthetic …