Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
J Wang, L Tan, X Yu, X Cao, B Jia, R Chen, J Li - Molecular Cancer, 2022 - Springer
Rationale Lung cancer is the most prevalent form of cancer and has a high mortality rate, making it a global public health concern. The N6-methyladenosine (m6A) modification is a …
Cancer immunogenomics is an emerging field that bridges genomics and immunology. The establishment of large-scale genomic collaborative efforts along with the development of …
L Zhang, M Lee, AY Maslov, C Montagna, J Vijg… - Nature …, 2024 - nature.com
Somatic mutations are the cause of cancer and have been implicated in other, noncancerous diseases and aging. While clonally expanded mutations can be studied by …
Background The human leukocyte antigen (HLA) is a highly polymorphic region, and HLA diversity may play a role in presenting tumour-associated peptides and inducing immune …
Y Zhang, M Liu, R Xie - BMC Public Health, 2023 - Springer
Abstract Introduction Even though cadmium (Cd) exposure and cellular senescence (telomere length) have been linked in previous studies, composite molecular aging …
P Ren, X Dong, J Vijg - Frontiers in Aging, 2022 - frontiersin.org
The genome of multicellular organisms carries the hereditary information necessary for the development of all organs and tissues and to maintain function in adulthood. To ensure the …
J Vijg, B Schumacher, A Abakir, M Antonov… - Trends in Molecular …, 2023 - cell.com
Genomes are inherently unstable and require constant DNA repair to maintain their genetic information. However, selective pressure has optimized repair mechanisms in somatic cells …
DNA damage has long been advocated as a molecular driver of aging. DNA damage occurs in a stochastic manner, and is therefore more likely to accumulate in longer genes. The …