Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Rationale Lung cancer is the most prevalent form of cancer and has a high mortality rate,
making it a global public health concern. The N6-methyladenosine (m6A) modification is a …

Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …

Somatic mutations are the cause of cancer and have been implicated in other,
noncancerous diseases and aging. While clonally expanded mutations can be studied by …

Background The human leukocyte antigen (HLA) is a highly polymorphic region, and HLA
diversity may play a role in presenting tumour-associated peptides and inducing immune …

Abstract Introduction Even though cadmium (Cd) exposure and cellular senescence
(telomere length) have been linked in previous studies, composite molecular aging …

The genome of multicellular organisms carries the hereditary information necessary for the
development of all organs and tissues and to maintain function in adulthood. To ensure the …

Genomes are inherently unstable and require constant DNA repair to maintain their genetic
information. However, selective pressure has optimized repair mechanisms in somatic cells …

DNA damage has long been advocated as a molecular driver of aging. DNA damage occurs
in a stochastic manner, and is therefore more likely to accumulate in longer genes. The …