The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Microorganisms are known to be natural oil producers in their cellular compartments.
Microorganisms that accumulate more than 20% w/w of lipids on a cell dry weight basis are …

Tropane alkaloids from nightshade plants are neurotransmitter inhibitors that are used for
treating neuromuscular disorders and are classified as essential medicines by the World …

Methanol-based biorefinery is a promising strategy to achieve carbon neutrality goals by
linking CO2 capture and solar energy storage. As a typical methylotroph, Pichia pastoris …

Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …

Natural products account for more than 50% of all small-molecule pharmaceutical agents
currently in clinical use. However, low availability often becomes problematic when a …

Highlights•Microbial cell factories can be tailored for producing certain 'drop-in'chemicals.•
Metabolic engineering has greatly enhanced the development of microbial cell …

Vitamin E is one of the most widely used vitamins. In the classical commercial synthesis of
vitamin E (α-tocopherol), the chemical synthesis of isophytol is the key technical barrier …

Microbial production of oleochemicals from renewable feedstocks remains an attractive
route to produce high-energy density, liquid transportation fuels and high-value chemical …

Highlights•Transporter proteins are essential for substrate uptake, product export, and
intercompartmental metabolite exchange.•Transporter activity of a cell can be engineered to …