GSK3: A potential target and pending issues for treatment of Alzheimer's disease

J Zhao, M Wei, M Guo, M Wang, H Niu… - CNS Neuroscience & …, 2024 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3), consisting of GSK3α and GSK3β subtypes, is
a complex protein kinase that regulates numerous substrates. Research has observed …

Lithium and its effects: does dose matter?

M Manchia, P Paribello, M Pinna, L Steardo Jr… - International journal of …, 2024 - Springer
Background Decades of clinical research have demonstrated the efficacy of lithium in
treating acute episodes (both manic and depressive), as well as in preventing recurrences of …

PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport

P Tziortzouda, J Steyaert, W Scheveneels, A Sicart… - Acta …, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which currently
lacks effective treatments. Mutations in the RNA-binding protein FUS are a common cause of …

Low-dose lithium adjunct to atypical antipsychotic treatment nearly improved cognitive impairment, deteriorated the gray-matter volume, and decreased the interleukin …

C Zhuo, S Hu, G Chen, L Yang, Z Cai, H Tian, D Jiang… - Schizophrenia, 2023 - nature.com
This study was conducted to investigate the effects of long-term low-dose lithium adjunct to
antipsychotic agent use on the cognitive performance, whole-brain gray-matter volume …

Low-dose lithium mono-and adjunctive therapies improve MK-801-induced cognitive impairment and schizophrenia-like behavior in mice-Evidence from altered …

C Zhuo, H Tian, G Chen, J Ping, L Yang, C Li… - Journal of Affective …, 2023 - Elsevier
Background Few studies have evaluated lithium either as monotherapy or in combination
with anti-psychotic agents to improve cognition in murine models of schizophrenia. Methods …

[HTML][HTML] Lithium Ions as Modulators of Complex Biological Processes: The Conundrum of Multiple Targets, Responsiveness and Non-Responsiveness, and the …

DA Hart - Biomolecules, 2024 - mdpi.com
Lithium is one of the lightest elements on Earth and it has been in the environment since the
formation of the galaxy. While a common element, it has not been found to be an essential …

[HTML][HTML] Role and Regulation of Glycogen Synthase Kinase-3 in Obesity-Associated Metabolic Perturbations

JJ Lemon, C Ogbu, M Gupte - Kinases and Phosphatases, 2024 - mdpi.com
Obesity has become a global epidemic, contributing to various metabolic diseases. Despite
existing therapies, the need to investigate new molecular targets to combat obesity …

The mechanisms of lithium action–an update

J Rybakowski - … in Psychiatry and Neurology/Farmakoterapia w …, 2024 - termedia.pl
Objectives. The paper aims to present the most important research on the mechanisms of
lithium action, published in the years 2019–2024. Literature review. The analysis of …

[PDF][PDF] MASTERARBEIT| MASTER'S THESIS

V Fleischhart - 2024 - phaidra.univie.ac.at
Alzheimer's Disease is an ageing-associated disease and is becoming more prevalent in
aged populations. The main characterisations are tau tangles and Aβ plagues. WNT and …