Circular dichroism sensing: Strategies and applications

JSSK Formen, JR Howard, EV Anslyn… - Angewandte Chemie …, 2024 - Wiley Online Library
The analysis of the absolute configuration, enantiomeric composition, and concentration of
chiral compounds are frequently encountered tasks across the chemical and health …

Tris (2-pyridylmethyl) amines as emerging scaffold in supramolecular chemistry

C Bravin, E Badetti, G Licini, C Zonta - Coordination Chemistry Reviews, 2021 - Elsevier
Abstract tris-(2-Pyridylmethyl) amine (usually abbreviated as TPA or TPMA) are ligands
which are emerging in many fields of chemistry because of their ability to form stable and …

Data-driven prediction of circular dichroism-based calibration curves for the rapid screening of chiral primary amine enantiomeric excess values

JR Howard, A Bhakare, Z Akhtar, C Wolf… - Journal of the …, 2022 - ACS Publications
Here, we describe the prediction of the circular dichroism (CD) response of a three-
component chiroptical sensor for enantiomeric excess (ee) determination of chiral amines …

Molecular Recognition and Chirality Sensing of Epoxides in Water Using Endo-Functionalized Molecular Tubes

LL Wang, Z Chen, WE Liu, H Ke… - Journal of the …, 2017 - ACS Publications
Chiral epoxides are important intermediates in chemistry and biology. The high-throughput
screening of asymmetric epoxidation conditions requires fast determination of the absolute …

A Data-Driven Approach to the Development and Understanding of Chiroptical Sensors for Alcohols with Remote γ-Stereocenters

JJ Dotson, EV Anslyn, MS Sigman - Journal of the American …, 2021 - ACS Publications
Dynamic covalent chemistry-based sensors have recently emerged as powerful tools to
rapidly determine the enantiomeric excess of organic small molecules. While a bevy of …

Rapid optical determination of enantiomeric excess, diastereomeric excess, and total concentration using dynamic-covalent assemblies: A demonstration using 2 …

BT Herrera, SR Moor, M McVeigh… - Journal of the …, 2019 - ACS Publications
Optical analysis of reaction parameters such as enantiomeric excess (ee), diastereomeric
excess (de), and yield are becoming increasingly useful as assays for differing functional …

Computer vision as a new paradigm for monitoring of solution and solid phase peptide synthesis

C Yan, C Fyfe, L Minty, H Barrington, C Jamieson… - Chemical …, 2023 - pubs.rsc.org
We report a strategy for the camera-enabled non-contact colourimetric reaction monitoring
and optimisation of amide bond formation, mediated by coupling reagents. For amide bond …

Organometallic Chirality Sensing via “Click”‐Like η6‐Arene Coordination with an Achiral Cp*Ru(II) Piano Stool Complex

E Nelson, JA Bertke, FY Thanzeel… - Angewandte Chemie …, 2024 - Wiley Online Library
Piano stool complexes have been studied over many years and found widespread
applications in organic synthesis, catalysis, materials and drug development. We now report …

Data-science-guided calibration curve prediction of an MLCT-based ee determination assay for chiral amines

JR Howard, JR Shuluk, A Bhakare, EV Anslyn - Chem, 2024 - cell.com
Circular dichroism (CD)-based enantiomeric excess (ee) determination assays are optical
alternatives to chromatographic ee determination in high-throughput screening (HTS) …

Enantioselective sensing of insect pheromones in water

BL Hickey, J Chen, Y Zou, AD Gill, W Zhong… - Chemical …, 2021 - pubs.rsc.org
An arrayed combination of water-soluble deep cavitands and cationic dyes has been shown
to optically sense insect pheromones at micromolar concentration in water. Machine …