Saponins and their role in biological processes in plants

A Faizal, D Geelen - Phytochemistry reviews, 2013 - Springer
Saponins are steroid and triterpenoid glycosides that display diverse biological activities.
The wide-spread occurrence in plants as well as the potential for pharmaceutical application …

Recent advances in steroidal saponins biosynthesis and in vitro production

S Upadhyay, GS Jeena, Shikha, RK Shukla - Planta, 2018 - Springer
Main conclusion Steroidal saponins exhibited numerous pharmacological activities due to
the modification of their backbone by different cytochrome P450s (P450) and UDP …

Open-chain steroidal glycosides, a diverse class of plant saponins

VL Challinor, JJ De Voss - Natural Product Reports, 2013 - pubs.rsc.org
Covering: up to September 2012 Saponins are an important class of plant natural products
that consist of a triterpenoid or steroidal skeleton that is glycosylated by varying numbers of …

Caco-2 Monolayer Permeability and Stability of Chamaelirium luteum (False Unicorn) Open-Chain Steroidal Saponins

TP Stockdale, VL Challinor, RP Lehmann… - ACS …, 2019 - ACS Publications
Herbal medicines, although significant components of health care for much of the global
populace, are still far less stringently regulated than conventional pharmaceuticals. Safety …

Structure and Bioactivity of Steroidal Saponins Isolated from the Roots of Chamaelirium luteum (False Unicorn)

VL Challinor, JMU Stuthe, PG Parsons… - Journal of Natural …, 2012 - ACS Publications
Phytochemical investigation of Chamaelirium luteum (“false unicorn”) resulted in the
isolation of 15 steroidal glycosides. Twelve of these (1, 2, 4–9, 11–13, and 15) are …

Structure and Absolute Configuration of Methyl (3R)-Malonyl-(13S)-hydroxycheilanth-17-en-19-oate, a Sesterterpene Derivative from the Roots of Aletris farinosa

VL Challinor, S Chap, RP Lehmann… - Journal of natural …, 2013 - ACS Publications
We report the isolation and structure elucidation of a new cheilanthane sesterterpene from
the roots of Aletris farinosa that possesses an unusual malonate half-ester functional group …

Biosynthetic insights provided by unusual sesterterpenes from the medicinal herb Aletris farinosa

VL Challinor, RC Johnston, PV Bernhardt… - Chemical …, 2015 - pubs.rsc.org
A series of novel sesterterpenes (2–6) have been isolated from the roots of Aletris farinosa
and structurally characterized by MS, NMR, and X-ray crystallography in conjunction with …

Revision of the absolute configurations of bethosides B and C and their aglycone

VL Challinor, PY Hayes, PV Bernhardt… - The Journal of …, 2011 - ACS Publications
The absolute stereochemistry of the steroidal saponins bethosides B and C was previously
assigned as (22 R, 25 R) on the basis of work that employed Horeau's method. Our studies …

New cholestane glycosides and sterols from the underground parts of Chamaelirium luteum and their cytotoxic activity

A Yokosuka, K Takagi, Y Mimaki - Journal of natural medicines, 2013 - Springer
Abstract Six new cholestane glycosides (1, 5, 6, 10, 12, and 13) and two new sterols (9 and
11), along with five known compounds (2–4, 7, and 8), were isolated from the underground …

Assignment of stereochemistry in open-chain steroidal saponins

VL Challinor, JJ De Voss - Pure and Applied Chemistry, 2012 - degruyter.com
The major phytochemical constituents of the widely used medicinal herb Chamaelirium
luteum (“false unicorn”) are open-chain cholesterol-derived steroidal saponins. These are …