Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Calcium alternans is associated with T-wave alternans and pulsus alternans, harbingers of
increased mortality in the setting of heart disease. Recent experimental, computational, and …

Sarcoplasmic reticulum (SR) Ca 2+ cycling is governed by the cardiac ryanodine receptor
(RyR2) and SR Ca 2+-ATPase (SERCA2a). Abnormal SR Ca 2+ cycling is thought to be the …

Beat-to-beat alternations in the amplitude of the cytosolic Ca2+ transient (Ca2+ alternans)
are thought to be the primary cause of cardiac alternans that can lead to cardiac arrhythmias …

Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon
where different regions of cardiac tissue exhibit an alternating sequence of APD that are out …

In conditions with abnormally increased activity of the cardiac ryanodine receptor (RyR2),
Ca2+/calmodulin-dependent protein kinase II (CaMKII) can contribute to a further …

Intracellular calcium (Ca) alternans in cardiac myocytes have been shown in many
experimental studies, and the mechanisms remain incompletely understood. We recently …

Mutations in the cardiac ryanodine receptor Ca2+ release channel (RyR2) can cause deadly
ventricular arrhythmias and atrial fibrillation (AF). The RyR2-P2328S mutation produces …

Abstract Aims Spontaneous Ca2+ release leads to afterdepolarizations and triggered
arrhythmia in catecholaminergic polymorphic ventricular tachycardia (CPVT). Irregular Ca2+ …

Abstract Aims The ryanodine receptor 2 (RyR2) is essential for cardiac muscle excitation–
contraction coupling; dysfunctional RyR2 participates in the development of inherited …