Epigenetics in ovarian cancer

Y Natanzon, EL Goode, JM Cunningham - Seminars in cancer biology, 2018 - Elsevier
Ovarian cancer is a disease with a poor prognosis and little progress has been made to
improve treatment. It is now recognized that there are several histotypes of ovarian cancer …

[HTML][HTML] DNA methylation profiles in ovarian cancer: implication in diagnosis and therapy

O Koukoura, DA Spandidos… - Molecular …, 2014 - spandidos-publications.com
Genetic alterations alone cannot account for the complexity of ovarian cancer. The potential
reversibility of epigenetic mechanisms makes them attractive candidates for the prevention …

Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16

R Kong, E Zhang, D Yin, L You, T Xu, W Chen, R Xia… - Molecular cancer, 2015 - Springer
Background Mounting evidence indicates that long noncoding RNAs (lncRNAs) could play a
pivotal role in cancer biology. However, the overall biological role and clinical significance of …

[PDF][PDF] LncRNA SNHG7 promotes the proliferation and inhibits apoptosis of gastric cancer cells by repressing the P15 and P16 expression.

MW Wang, J Liu, Q Liu, QH Xu, TF Li… - European Review for …, 2017 - europeanreview.org
OBJECTIVE: To investigate the relative expression of long non-coding small nucleolar RNA
host gene 7 (lncRNA SNHG7) in gastric cancer tissues and cells, the effect of lncRNA …

[PDF][PDF] LncRNA SNHG7 promotes the proliferation of esophageal cancer cells and inhibits its apoptosis.

LJ Xu, XJ Yu, B Wei, HX Hui, Y Sun… - European Review for …, 2018 - europeanreview.org
OBJECTIVE: Our research studied the expression of long noncoding RNA (lncRNA) SNHG7
in esophageal cancer cells and tissues. The effect of lncRNA SNHG7 on proliferation and …

High LET 56Fe ion irradiation induces tissue‐specific changes in DNA methylation in the mouse

F Lima, D Ding, W Goetz, AJ Yang… - Environmental and …, 2014 - Wiley Online Library
DNA methylation is an epigenetic mechanism that drives phenotype and that can be altered
by environmental exposures including radiation. The majority of human radiation exposures …

CIP/KIP and INK4 families as hostages of oncogenic signaling

L Csergeová, D Krbušek, R Janoštiak - Cell Division, 2024 - Springer
Abstract CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-
established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK …

Clinical and prognostic effects of CDKN2A, CDKN2B and CDH13 promoter methylation in ovarian cancer: a study using meta-analysis and TCGA data

L Xia, W Zhang, L Gao - Biomarkers, 2019 - Taylor & Francis
Background: Promoter methylation of tumour suppressor genes (TSGs) CDKN2A, CDKN2B
and CDH13 has been reported in ovarian cancer. However, the clinicopathological …

Expression of DNA methyltransferase 3B isoforms is associated with DNA satellite 2 hypomethylation and clinical prognosis in advanced high-grade serous ovarian …

VM Del Castillo Falconi, J Díaz-Chávez… - International Journal of …, 2022 - mdpi.com
Alterations in DNA methylation are critical for the carcinogenesis of ovarian tumors,
especially ovarian carcinoma (OC). DNMT3B, a de novo DNA methyltransferase (DNMT) …

[HTML][HTML] Epigenetic Modulation of Estrogen Receptor Signaling in Ovarian Cancer

M Skrzypczak, E Wolinska, Ł Adaszek… - International Journal of …, 2024 - mdpi.com
Ovarian cancer remains one of the leading causes of cancer-related deaths in women.
There are several processes that are described to have a causal relationship in ovarian …