The rapid growth of the literature on positive interventions to increase “happiness” has
suggested the need for an overarching conceptual framework to integrate the many and …

While chronic pain is considered by some to be a CNS disease, little is understood about
underlying neurobiological mechanisms. Addiction models have heuristic value in this …

Objective: Loss of pleasure or interest in activities (ie, anhedonia) is a risk factor for
suicidality, treatment nonresponse, and relapse. Extant treatments that focus on reducing …

Objective: Determine whether a novel psychosocial treatment for positive affect improves
clinical status and reward sensitivity more than a form of cognitive behavioral therapy that …

Anhedonia, or loss of interest or pleasure in usual activities, is characteristic of depression,
some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a …

Objective: Evidence from anti-inflammatory drug trials for the treatment of depression has
been inconsistent. This may be ascribed to the differing symptom-specific effects of …

Hundreds of thousands of clinicians and graduate students have relied on this text--now
significantly revised with more than 50% new material--to learn the fundamentals of …

Mental imagery is an experience like perception in the absence of a percept. It is a
ubiquitous feature of human cognition, yet it has been relatively neglected in the etiology …

Background Research suggests that the positive affect system may be an important yet
underexplored treatment target in anxiety and depression. Existing interventions primarily …

BackgroundStudies investigating the link between depressive symptoms and inflammation
have yielded inconsistent results, which may be due to two factors. First, studies differed …