Applications of microfluidics and organ-on-a-chip in cancer research
Taking the life of nearly 10 million people annually, cancer has become one of the major
causes of mortality worldwide and a hot topic for researchers to find innovative approaches …
causes of mortality worldwide and a hot topic for researchers to find innovative approaches …
Application of FRET biosensors in mechanobiology and mechanopharmacological screening
Extensive studies have shown that cells can sense and modulate the biomechanical
properties of the ECM within their resident microenvironment. Thus, targeting the …
properties of the ECM within their resident microenvironment. Thus, targeting the …
Molecular mechanocytometry using tension-activated cell tagging
Flow cytometry is used routinely to measure single-cell gene expression by staining cells
with fluorescent antibodies and nucleic acids. Here, we present tension-activated cell …
with fluorescent antibodies and nucleic acids. Here, we present tension-activated cell …
Scalable fabrication and use of 3D structured microparticles spatially functionalized with biomolecules
Microparticles with defined shapes and spatial chemical modification can interface with cells
and tissues at the cellular scale. However, conventional methods to fabricate shaped …
and tissues at the cellular scale. However, conventional methods to fabricate shaped …
Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin–mediated engagement of Piezo1
M Ezzo, K Spindler, JB Wang, D Lee, G Pecoraro… - Science …, 2024 - science.org
Fibrosis—excessive scarring after injury—causes> 40% of disease-related deaths
worldwide. In this misguided repair process, activated fibroblasts drive the destruction of …
worldwide. In this misguided repair process, activated fibroblasts drive the destruction of …
Tracking single hiPSC-derived cardiomyocyte contractile function using CONTRAX an efficient pipeline for traction force measurement
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) are
powerful in vitro models to study the mechanisms underlying cardiomyopathies and …
powerful in vitro models to study the mechanisms underlying cardiomyopathies and …
Toward deep biophysical cytometry: prospects and challenges
The biophysical properties of cells reflect their identities, underpin their homeostatic state in
health, and define the pathogenesis of disease. Recent leapfrogging advances in …
health, and define the pathogenesis of disease. Recent leapfrogging advances in …
Exploring Mechanical Responses of Cells to Geometric Information Using Micropatterned DNA-Based Molecular Tension Probes
The geometric shape of a cell is strongly influenced by the cytoskeleton, which, in turn, is
regulated by integrin-mediated cell–extracellular matrix (ECM) interactions. To investigate …
regulated by integrin-mediated cell–extracellular matrix (ECM) interactions. To investigate …
A review on microfluidics manipulation of the extracellular chemical microenvironment and its emerging application to cell analysis
Spatiotemporal manipulation of extracellular chemical environments with simultaneous
monitoring of cellular responses plays an essential role in exploring fundamental biological …
monitoring of cellular responses plays an essential role in exploring fundamental biological …
Striae distensae: in vitro study and assessment of combined treatment with sodium ascorbate and platelet-rich plasma on fibroblasts
S La Padula, B Hersant, C Pizza, C Chesné… - Aesthetic plastic …, 2021 - Springer
Introduction Striae distensae (SD) appear clinically as parallel striae, lying perpendicular to
the tension lines of the skin. SD evolve into two clinical phases, an initial inflammatory phase …
the tension lines of the skin. SD evolve into two clinical phases, an initial inflammatory phase …