Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and are the
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …

The human testis undergoes dramatic developmental and structural changes during
puberty, including proliferation and maturation of somatic niche cells, and the onset of …

Meiosis facilitates diversity across individuals and serves as a major driver of evolution.
However, understanding how meiosis begins is complicated by fundamental differences that …

DNA methylation plays a critical role in spermatogenesis, as evidenced by the male sterility
of DNA methyltransferase (DNMT) mutant mice. Here, we report a division of labor in the …

Pro-spermatogonia (SG) serve as the gateway to spermatogenesis. Using single-cell RNA
sequencing (RNAseq), we studied the development of ProSG, their SG descendants and …

Nutrient starvation drives yeast meiosis, whereas retinoic acid (RA) is required for
mammalian meiosis through its germline target Stra8. Here, by using single-cell …

Abstract Background Spermatogonial stem cells (SSCs) provide a foundation for robust and
continual spermatogenesis in mammals. SSCs self-renew to maintain a functional stem cell …

The molecular machinery and chromosome structures carrying out meiosis are frequently
conserved from yeast to mammals. However, signals initiating meiosis appear divergent …

Retinoic acid (RA) is the proposed mammalian 'meiosis inducing substance'. However,
evidence for this role comes from studies in the fetal ovary, where germ cell differentiation …

Since their initial description by Enrico Sertoli in 1865, Sertoli cells have continued to
enchant testis biologists. Testis size and germ cell carrying capacity are intimately tied to …