Microgravity-induced fluid shift and ophthalmic changes

ES Nelson, L Mulugeta, JG Myers - Life, 2014 - mdpi.com
Although changes to visual acuity in spaceflight have been observed in some astronauts
since the early days of the space program, the impact to the crew was considered minor …

Ocular blood flow as a clinical observation: Value, limitations and data analysis

A Harris, G Guidoboni, B Siesky, S Mathew… - Progress in retinal and …, 2020 - Elsevier
Alterations in ocular blood flow have been identified as important risk factors for the onset
and progression of numerous diseases of the eye. In particular, several population-based …

[HTML][HTML] Intraocular pressure, blood pressure, and retinal blood flow autoregulation: a mathematical model to clarify their relationship and clinical relevance

G Guidoboni, A Harris, S Cassani… - … & visual science, 2014 - jov.arvojournals.org
Purpose.: This study investigates the relationship between intraocular pressure (IOP) and
retinal hemodynamics and predicts how arterial blood pressure (BP) and blood flow …

Neurodegenerative disorders of the eye and of the brain: a perspective on their fluid-dynamical connections and the potential of mechanism-driven modeling

G Guidoboni, R Sacco, M Szopos, L Sala… - Frontiers in …, 2020 - frontiersin.org
Neurodegenerative disorders (NDD) such as Alzheimer's and Parkinson's diseases are
significant causes of morbidity and mortality worldwide. The pathophysiology of NDD is still …

A poroelastic model for the perfusion of the lamina cribrosa in the optic nerve head

P Causin, G Guidoboni, A Harris, D Prada… - Mathematical …, 2014 - Elsevier
In this work we present a mathematical model for the coupling between biomechanics and
hemodynamics in the lamina cribrosa, a thin porous tissue at the base of the optic nerve …

[图书][B] A comprehensive physically based approach to modeling in bioengineering and life sciences

R Sacco, G Guidoboni, AG Mauri - 2019 - books.google.com
A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life
Sciences provides a systematic methodology to the formulation of problems in biomedical …

Effect of intraocular pressure on the hemodynamics of the central retinal artery: a mathematical model

G Guidoboni, A Harris, L Carichino, Y Arieli… - Mathematical …, 2014 - aimsciences.org
Retinal hemodynamics plays a crucial role in the pathophysiology of several ocular
diseases. There are clear evidences that the hemodynamics of the central retinal artery …

Retinal oximetry in glaucoma: investigations and findings reviewed

A Shughoury, S Mathew, J Arciero… - Acta …, 2020 - Wiley Online Library
Abnormalities of the retinal blood supply have been widely implicated in primary open‐
angle glaucoma (POAG). Impaired blood supply to the retina and optic nerve head (ONH) …

Mathematical modeling of aqueous humor flow and intraocular pressure under uncertainty: towards individualized glaucoma management

M Szopos, S Cassani, G Guidoboni… - Journal for Modeling in …, 2016 - hal.science
Purpose: The aim of the proposed analysis is to provide both a qualitative description and a
quantitative assessment of how variations in aqueous humor (AH) flow parameters influence …

Blood flow regulation and oxygen transport in a heterogeneous model of the mouse retina

BC Fry, A Harris, B Siesky, J Arciero - Mathematical biosciences, 2020 - Elsevier
Elevated intraocular pressure is the primary risk factor for glaucoma, yet vascular health and
ocular hemodynamics have also been established as important risk factors for the disease …