Type 2 diabetes and reduced exercise tolerance: a review of the literature through an integrated physiology approach
The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) is well
established. Early in the course of the diabetic disease, some degree of impaired exercise …
established. Early in the course of the diabetic disease, some degree of impaired exercise …
What do we know about serotonin?
C Jonnakuty, C Gragnoli - Journal of cellular physiology, 2008 - Wiley Online Library
The present review focuses on what is known of basic serotonin physiology in the human
body. Here, we describe serotonin biochemistry and metabolism and summarize the results …
body. Here, we describe serotonin biochemistry and metabolism and summarize the results …
The role of somatosensory innervation of adipose tissues
Adipose tissues communicate with the central nervous system to maintain whole-body
energy homeostasis. The mainstream view is that circulating hormones secreted by the fat …
energy homeostasis. The mainstream view is that circulating hormones secreted by the fat …
TRPA1 underlies a sensing mechanism for O2
Oxygen (O2) is a prerequisite for cellular respiration in aerobic organisms but also elicits
toxicity. To understand how animals cope with the ambivalent physiological nature of O2, it …
toxicity. To understand how animals cope with the ambivalent physiological nature of O2, it …
Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure
HJ Wang, W Wang, KG Cornish, GJ Rozanski… - …, 2014 - Am Heart Assoc
The enhanced cardiac sympathetic afferent reflex (CSAR) contributes to the exaggerated
sympathoexcitation in chronic heart failure (CHF). Increased sympathoexcitation is positively …
sympathoexcitation in chronic heart failure (CHF). Increased sympathoexcitation is positively …
Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury
Background—Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during
cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO …
cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO …
Methods of assessing vagus nerve activity and reflexes
MW Chapleau, R Sabharwal - Heart failure reviews, 2011 - Springer
The methods used to assess cardiac parasympathetic (cardiovagal) activity and its effects on
the heart in both humans and animal models are reviewed. Heart rate (HR)-based methods …
the heart in both humans and animal models are reviewed. Heart rate (HR)-based methods …
TRP channel and cardiovascular disease
H Watanabe, M Murakami, T Ohba, Y Takahashi… - Pharmacology & …, 2008 - Elsevier
The transient receptor potential (TRP) channel superfamily consists of 28 mammalian cation
channels and is expressed in almost every tissue, including the heart and vasculature; most …
channels and is expressed in almost every tissue, including the heart and vasculature; most …
Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia
J Yagi, HN Wenk, LA Naves, EW McCleskey - Circulation research, 2006 - Am Heart Assoc
Acid-sensing ion channel 3 (ASIC3) is highly expressed on sensory neurons that innervate
heart and skeletal muscle and, therefore, is proposed to detect lactic acidosis and to …
heart and skeletal muscle and, therefore, is proposed to detect lactic acidosis and to …
Testing the autonomic nervous system
R Freeman, MW Chapleau - Handbook of clinical neurology, 2013 - Elsevier
Autonomic testing is used to define the role of the autonomic nervous system in diverse
clinical and research settings. Because most of the autonomic nervous system is …
clinical and research settings. Because most of the autonomic nervous system is …