Immunotherapy has emerged as the fifth pillar of cancer treatment alongside surgery,
radiotherapy, chemotherapy, and targeted therapy. Immune checkpoint inhibitors are the …

Simple Summary Breast cancer is one of the most prevalent cancers worldwide, surpassing
lung cancer as the leading cause of overall cancer incidence. Available possible treatments …

The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche
remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival …

Motivation Cancer subtypes were usually defined based on molecular characterization of
single omic data. Increasingly, measurements of multiple omic profiles for the same cohort …

Studies in shift workers and model organisms link circadian disruption to breast cancer.
However, molecular circadian rhythms in noncancerous and cancerous human breast …

Spatially resolved transcriptomics (SRT) technology enables us to gain novel insights into
tissue architecture and cell development, especially in tumors. However, lacking …

Background Facing the diversity of omics data and the difficulty of selecting one result over
all those produced by several methods, consensus strategies have the potential to reconcile …

Breast cancer is a highly heterogeneous disease. Although differences between intrinsic
breast cancer subtypes have been well studied, heterogeneity within each subtype …

Identifying patients at risk for metastatic relapse is a critical medical need. We identified a
common missense germline variant in proprotein convertase subtilisin/kexin type 9 …

Background Heterogeneity of immune gene expression patterns of luminal breast cancer
(BC), which is clinically heterogeneous and overall considered as low immunogenic, has not …