Objective The original European League Against Rheumatism recommendations for
managing fibromyalgia assessed evidence up to 2005. The paucity of studies meant that …

Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Background This review is one of a series on drugs used to treat chronic neuropathic pain.
Estimates of the population prevalence of chronic pain with neuropathic components range …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Background Gabapentin is commonly used to treat neuropathic pain (pain due to nerve
damage). This review updates a review published in 2014, and previous reviews published …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Answer questions and earn CME/CNE The American Cancer Society Head and Neck
Cancer Survivorship Care Guideline was developed to assist primary care clinicians and …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …