A number of techniques have been employed to locate active sites and binding sites for
enzyme-substrate complexes. These techniques include X-ray crystallography of the …

Publisher Summary Many excellent reviews and monographs have been written describing
the chemistry and biological activity of various antisense and antigene oligonucleotides …

The antisense strategy has been applied to regulate gene expression in a sequence specific
manner, which enables suppression of the proliferation of cancer cells and exploration of the …

Oligodeoxyribonucleotides containing thymidine and 8-oxo-2′′-deoxyadenosine can form
pyr-pur-pyr type triplexes with double-stranded DNA. Unlike triplexes whose third strands …

Antisense oligo-2 '-O-methylribonucleotides and their methylphosphonate derivatives show
high binding affinities for their complementary targets under essentially physiological …

We have investigated the role of purines in interstrand complex formation with regard to
substitution of the negatively-charged, phosphodiester backbone by a nonionic …

This review includes literature data on main types of reagents inducing covalent cross-links
of nucleic acids. Reactivity of cross-linking agents, preferable sites for their binding, and …

Antisense oligonucleotides that selectively inhibit gene expression are a genetic approach
for disease treatment and prevention. However, their use as therapeutic agents is …

To provide a solid support for automated synthesis of 3'-(aminoalkyl)-modified
oligonucleoside methylphosphonates, controlled pore glass beads were functionalized with …

Published data on the main types of reagents capable of introducing covalent interstrand
cross links into nucleic acids (NA) are summarized in the present review. The reactivity of …