Metabolic regulation of the immune system in health and diseases: mechanisms and interventions

T Hu, CH Liu, M Lei, Q Zeng, L Li, H Tang… - Signal Transduction and …, 2024 - nature.com
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other
metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic …

Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease

DC Shippy, AH Evered, TK Ulland - Immunological Reviews, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a degenerative brain disorder and the most common form of
dementia. AD pathology is characterized by senile plaques and neurofibrillary tangles …

In vitro evaluation and bioinformatics analysis of schiff bases bearing pyrazole scaffold as bioactive agents: antioxidant, anti-diabetic, anti-alzheimer, and anti-arthritic

HM Alkahtani, AA Almehizia, MA Al-Omar… - Molecules, 2023 - mdpi.com
In continuation of our research programs for the discovery, production, and development of
the pharmacological activities of molecules for various disease treatments, Schiff bases and …

The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons

M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …

Minding the Gap: Exploring Neuroinflammatory and Microglial Sex Differences in Alzheimer's Disease

EG Reed, PR Keller-Norrell - International Journal of Molecular Sciences, 2023 - mdpi.com
Research into Alzheimer's Disease (AD) describes a link between AD and the resident
immune cells of the brain, the microglia. Further, this suspected link is thought to have …

[HTML][HTML] Aging, sex, metabolic and life experience factors: contributions to neuro-inflammaging in Alzheimer's disease research

PH Singhaarachchi, P Antal, F Calon… - Neuroscience & …, 2024 - Elsevier
Alzheimer's disease (AD) is prevalent around the world, yet our understanding of the
disease is still very limited. Recent work suggests that the cornerstone of AD may include the …

Zinc utilization by microglia in Alzheimer's disease

DC Shippy, SF Oliai, TK Ulland - Journal of Biological Chemistry, 2024 - ASBMB
Alzheimer's disease (AD) is the most common form of dementia defined by two key
pathological characteristics in the brain, amyloid-β (Aβ) plaques and neurofibrillary tangles …

HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV

Y Cheng, J Jung, L Guo, DD Shuboni-Mulligan… - Brain, Behavior, and …, 2025 - Elsevier
Chronic HIV infection can dysregulate lipid/cholesterol metabolism in the peripheral system,
contributing to the higher incidences of diabetes and atherosclerosis in HIV (+) individuals …

Characterization of gut microbiota dynamics in an Alzheimer's disease mouse model through clade-specific marker-based analysis of shotgun metagenomic data

F Favero, A Re, MS Dason, T Gravina, M Gagliardi… - Biology Direct, 2024 - Springer
Alzheimer's disease (AD) is a complex neurodegenerative disorder significantly impairing
cognitive faculties, memory, and physical abilities. To characterize the modulation of the gut …

SCGB1A1 as a novel biomarker and promising therapeutic target for the management of HNSCC

J Wang, Q Xu, J Yu, A Xu, L Yu, Z Chen… - Oncology …, 2024 - spandidos-publications.com
Head and neck cancer (HNC) is the sixth most common type of cancer worldwide, and head
and neck squamous cell carcinoma (HNSCC) accounts for 90% of HNC cases. Furthermore …