Assays for tumour necrosis factor and related cytokines

A Meager, H Leung, J Woolley - Journal of immunological methods, 1989 - Elsevier
In the middle of the last decade, Carswell et al.(1975) reported the identification of a
cytotoxin (CTX) in the sera of mice infected with bacille Calmette-Gu6rin (BCG) and …

Elevated tumour necrosis factor‐alpha (TNF‐α) biological activity in psoriatic skin lesions

P Ettehadi, MW Greaves, D Wallach… - Clinical & …, 1994 - Wiley Online Library
Lesions of the common inflammatory skin disease psoriasis are characterized by epidermal
hyperproliferation, leucocyte adhesion molecule expression and leucocyte infiltration. The …

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T‐cells

D Eastwood, L Findlay, S Poole, C Bird… - British journal of …, 2010 - Wiley Online Library
BACKGROUND AND PURPOSE In 2006, a life‐threatening 'cytokine storm', not predicted by
pre‐clinical safety testing, rapidly occurred in all six healthy volunteers during the phase I …

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine …

MN Woodroofe, GS Sarna, M Wadhwa… - Journal of …, 1991 - Elsevier
In vivo levels of interleukin-1 (IL-1) and IL-6, present in the interstitial spaces of brain, have
been repeatedly monitored up to 7 days after insertion of a microdialysis probe, designed to …

Regulation of cytokine release from mononuclear cells by the iron-binding protein lactoferrin

SP Crouch, KJ Slater, J Fletcher - 1992 - ashpublications.org
The iron-binding protein lactoferrin (Lf) is a constituent of neutrophil secondary granules and
is discharged into the surrounding medium when neutrophils are activated. Lf released from …

Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies

J Le, J Vilcek, P Dadonna, J Ghrayeb, D Knight… - US Patent …, 1997 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46249950&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Enhanced tumour necrosis factor and interleukin-1 in fulminant hepatic failure

Y Muto, A Meager, KT Nouri-Aria, GJM Alexander… - The Lancet, 1988 - Elsevier
Sepsis and endotoxaemia are common in fulminant hepatic failure (FHF) and may contribute
to multisystem disease in such patients. Tumour necrosis factor (TNF) is a probable mediator …

Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma

RD Leek, R Landers, SB Fox, F Ng, AL Harris… - British journal of …, 1998 - nature.com
Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated
by a complex network of factors produced by both stromal cells and neoplastic cells within …

Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM

MJ Hussain, M Peakman, H Gallati, SSS Lo, M Hawa… - Diabetologia, 1996 - Springer
To determine whether cytokines could have a role in the development of insulin-dependent
diabetes mellitus (IDDM), we measured serum levels of cytokines derived from T helper 1 …

Cytokines in proliferative vitreoretinopathy

GA Limb, BC Little, A Meager, JA Ogilvie… - Eye, 1991 - nature.com
This study determined the presence of interleukin 1 (IL-1), interleukin 6 (IL-6), tumour
necrosis factor α (TNFa), tumour necrosis factor β (TNFβ), interferon γ (IFNγ), transforming …