In the present review, we focus on the phenomenon of chromothripsis, a new type of
complex chromosomal rearrangements. We discuss the challenges of chromothripsis …

Background During the last decade, genome sequencing projects in cancer genomes as
well as in patients with congenital diseases and healthy individuals have led to the …

Chromothripsis is a recently identified mutational phenomenon, by which a presumably
single catastrophic event generates extensive genomic rearrangements of one or a few …

Ionising radiation (IR) is a recognised carcinogen responsible for cancer development in
patients previously treated using radiotherapy, and in individuals exposed as a result of …

Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one
or few chromosomes in multiple fragments and consequent random rejoining and repair …

Replication errors and various genotoxins cause DNA double-strand breaks (DSBs) where
error-prone repair creates genomic mutations, most frequently focal deletions, and defective …

In recent years, the paradigm that genomic abnormalities in cancer cells arise through
progressive accumulation of mutational events has been challenged by the discovery of …

Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered
genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic …

Background Whole-genome sequencing (WGS) is a powerful method for revealing the
diversity and complexity of the somatic mutation burden of tumours. Here, we investigated …

Chromothripsis is a mitotic catastrophe that arises from multiple double strand breaks and
incorrect re-joining of one or a few chromosomes. We report on incidence, distribution, and …