Thiophene-based derivatives as anticancer agents: An overview on decade's work
S Pathania, PA Chawla - Bioorganic Chemistry, 2020 - Elsevier
Heterocyclic compounds hold a pivotal place in medicinal chemistry due to their wide range
of biological activities and thus, are exhaustively explored in the field of drug design and …
of biological activities and thus, are exhaustively explored in the field of drug design and …
Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity
HSA ElZahabi, MS Nafie, D Osman… - European Journal of …, 2021 - Elsevier
This work presents the design and synthesis of a series of new quinazolin-4-one derivatives,
based on the established effectiveness of quinazoline-based small molecules as anticancer …
based on the established effectiveness of quinazoline-based small molecules as anticancer …
Experimental, quantum chemical and molecular simulation studies on the action of arylthiophene derivatives as acid corrosion inhibitors
The corrosion inhibition properties of two newly synthesized arylthiophene derivatives,
namely 2-(4-amidinophenyl)-5-[(4-dimethylamino) phenyl] thiophene hydrochloride (MA …
namely 2-(4-amidinophenyl)-5-[(4-dimethylamino) phenyl] thiophene hydrochloride (MA …
New bithiophene derivative attenuated Alzheimer's disease induced by aluminum in a rat model via antioxidant activity and restoration of neuronal and synaptic …
K AbdEl-Raouf, HSH Farrag, R Rashed… - Journal of Trace …, 2024 - Elsevier
Background One of the hypotheses that leads to an increased incidence of Alzheimer's
disease (AD) is the accumulation of aluminum in the brain's frontal cortex. The present study …
disease (AD) is the accumulation of aluminum in the brain's frontal cortex. The present study …
Design, molecular modeling and anticancer evaluation of thieno [2, 3-d] pyrimidine derivatives as inhibitors of topoisomerase II
SA El-Metwally, AK Khalil, WM El-Sayed - Bioorganic Chemistry, 2020 - Elsevier
Abstract Synthesis of 4-(3, 5-dimethyl-1H-pyrazol-1-yl)-5, 6, 7, 8-tetrahydrobenzo [4, 5]
thieno [2, 3-d] pyrimidine 1 and its functionalized reactions as nucleophile with various …
thieno [2, 3-d] pyrimidine 1 and its functionalized reactions as nucleophile with various …
Novel cationic aryl bithiophene/terthiophene derivatives as corrosion inhibitors by chemical, electrochemical and surface investigations
Two novel bithienyl fluorobenzamidine derivatives namely, 4-([2, 2′: 5′, 2′′-
terthiophen]-5-yl)-2-fluorobenzamidine hydrochloride salt (MA-1615), 5′-(4-amidino-3 …
terthiophen]-5-yl)-2-fluorobenzamidine hydrochloride salt (MA-1615), 5′-(4-amidino-3 …
Fabrication of novel Fe (III), Co (II), Hg (II), and Pd (II) complexes based on water‐soluble ligand (NaH2PH): structural characterization, cyclic voltammetric, powder X …
Sodium4‐hydroxy‐3‐([2‐picolinoylhydrazineylidene] methyl) benzenesulfonate (NaH2PH)
was synthesized as a novel water‐soluble ligand, by the condensation of picolinohydrazide …
was synthesized as a novel water‐soluble ligand, by the condensation of picolinohydrazide …
Investigation (IR, UV-visible, fluorescence, X-ray diffraction and thermogravimetric) studies of Mn (II), Fe (III) and Cr (III) complexes of thiosemicarbazone derived from …
Trivalent chromium, iron and divalent manganese complexes of thiosemicarbazone ligand
(NaH 3 PyTSC) were synthesized. The complexes were considered by analytical and …
(NaH 3 PyTSC) were synthesized. The complexes were considered by analytical and …
Preparation, characterization, and computational study on transition metal complexes derived from thiophene Schiff base and evaluation of their cytotoxicity against …
FN Sayed, AM Ashmawy, GG Mohamed… - Applied …, 2024 - Wiley Online Library
Novel thiophene Schiff base ligand (L) was synthesized through the condensation of 2‐
thiophene‐methylamine and 3‐formyl‐4‐methoxyphenylboronic acid. Transition metal …
thiophene‐methylamine and 3‐formyl‐4‐methoxyphenylboronic acid. Transition metal …
New N-(1, 3, 4-thiadiazol-2-yl) furan-2-carboxamide derivatives as potential inhibitors of the VEGFR-2
The present study reports the synthesis and biological evaluation of a new series of novel N-
(1, 3, 4-thiadiazol-2-yl) furan-2-carboxamide derivatives. The reactions were executed under …
(1, 3, 4-thiadiazol-2-yl) furan-2-carboxamide derivatives. The reactions were executed under …