The prevalence of obesity has increased globally over the last 2 decades. Although the body
mass index has been a convenient and simple index of obesity at the population level …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate
energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid …

Maintenance of a homeostatic body core temperature is a critical brain function
accomplished by a central neural network. This orchestrates a complex behavioral and …

Cold-induced thermogenesis (CIT) is widely studied as a potential avenue to treat obesity,
but a thorough understanding of the metabolic changes driving CIT is lacking. Here, we …

The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …

Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Cryotherapy is utilized as a physical intervention in the treatment of injury and exercise
recovery. Traditionally, ice is used in the treatment of musculoskeletal injury while cold water …

Recruitment of brown adipose tissue (BAT) has emerged as a potential tool to combat
obesity and associated metabolic complications. Short-term cold acclimation has been …