Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS‐CoV‐2
Emergence of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection,
COVID‐19, has become the global panic since December 2019, which urges the global …
COVID‐19, has become the global panic since December 2019, which urges the global …
Problems of pathogenesis and pathogenetic therapy of COVID-19 from the perspective of the general theory of pathological systems (general pathological processes)
E Gusev, A Sarapultsev, D Hu… - International journal of …, 2021 - mdpi.com
The COVID-19 pandemic examines not only the state of actual health care but also the state
of fundamental medicine in various countries. Pro-inflammatory processes extend far …
of fundamental medicine in various countries. Pro-inflammatory processes extend far …
Interleukin-1 in COVID-19 Infection: Immunopathogenesis and Possible Therapeutic Perspective
The newfound coronavirus disease 2019 (COVID-19), initiated by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is an international public health concern …
syndrome coronavirus 2 (SARS-CoV-2), is an international public health concern …
Diacerein attenuate LPS-induced acute lung injury via inhibiting ER stress and apoptosis: Impact on the crosstalk between SphK1/S1P, TLR4/NFκB/STAT3, and …
NS Youssef, AS Elzaitony, NAA Baky - Life Sciences, 2022 - Elsevier
Aims Acute lung injury (ALI) is a life-threatening clinical problem with high mortality rate and
limited treatments or preventive options that represents a major challenge for clinicians …
limited treatments or preventive options that represents a major challenge for clinicians …
Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal
GA Mohamed Kamel, E Harahsheh… - Molecular Biology Reports, 2022 - Springer
Background Acetaminophen (APAP) is a worldwide antipyretic as well as an analgesic
medication. It has been extensively utilized during the outbreak of coronavirus 2019 (COVID …
medication. It has been extensively utilized during the outbreak of coronavirus 2019 (COVID …
Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review
A Yarmohammadi, M Yarmohammadi, S Fakhri… - European journal of …, 2021 - Elsevier
As an emerging global health crisis, coronavirus disease 2019 (COVID-19) has been
labeled a worldwide pandemic. Growing evidence is revealing further pathophysiological …
labeled a worldwide pandemic. Growing evidence is revealing further pathophysiological …
[HTML][HTML] Diacerein protects rats with liver ischemia/reperfusion damage: down-regulation of TLR4/NFκ-B signaling pathway
Purpose Liver ischemia-reperfusion (I/R) injury is an inescapable problem. Diacerein, a
chondro-protective drug, has antioxidant and anti-inflammatory effects. Its effect on liver I/R …
chondro-protective drug, has antioxidant and anti-inflammatory effects. Its effect on liver I/R …
Betaine-and l-carnitine-based ionic liquids as solubilising and stabilising agents for the formulation of antimicrobial eye drops containing diacerein
B Grassiri, A Mezzetta, G Maisetta, C Migone… - International Journal of …, 2023 - mdpi.com
The therapeutic efficacy of topically administered drugs, however powerful, is largely
affected by their bioavailability and, thus, ultimately, on their aqueous solubility and stability …
affected by their bioavailability and, thus, ultimately, on their aqueous solubility and stability …
Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer
M Suaya, GM Sánchez, A Vila, A Amante… - Cell Death & …, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Of particular interest …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Of particular interest …
[HTML][HTML] Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
N Barakat, LAA Barakat, MM Zakaria… - Saudi Journal of …, 2021 - Elsevier
Cisplatin is an antineoplastic medicine used for solid tumor treatment. The main side effect
that limits its dose is nephrotoxicity. Diacerein has been used for the treatment of joint …
that limits its dose is nephrotoxicity. Diacerein has been used for the treatment of joint …