Membrane proteins play key roles in human health, contributing to cellular signaling, ATP
synthesis, immunity, and metabolite transport. Protein folding is the pivotal early step for their …

Intracellular membranes composing organelles of eukaryotes include membrane proteins
playing crucial roles in physiological functions. However, a comprehensive understanding of …

Oxidative modifications can disrupt protein folds and functions, and are strongly associated
with human aging and diseases. Conventional oxidation pathways typically involve the free …

Optical microcavities, particularly whispering gallery mode (WGM) microcavities enhanced
by plasmonic nanorods, are emerging as powerful platforms for single‐molecule sensing …

Polymer-based molecular tweezers have emerged as a prominent research area due to
their enhanced ability to form host–guest complexes, driven by advancements in their …

Transmembrane transporter proteins are essential for maintaining cellular homeostasis and,
as such, are key drug targets. Many transmembrane transporter proteins are known to …

In this issue of Structure, Blaimschein et al. elucidate the chaperoning function of the
insertase YidC during the insertion and folding of the melibiose permease MelB. Their single …

Molecular tethering of a single membrane protein between the glass surface and a magnetic
bead is essential for studying the structural dynamics of membrane proteins using magnetic …

Single-molecule magnetic tweezers have recently been adapted for monitoring the
interactions between transmembrane helices of membrane proteins within lipid bilayers. In …

Elucidating the folding energy landscape of membrane proteins is essential to the
understanding of the proteins' stabilizing forces, folding mechanisms, biogenesis, and …