Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from
atherosclerosis that is frequently but not always associated with diabetes mellitus, chronic …

Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic
processes, including immunomodulation and cell proliferation. Tumors create an adenosine …

Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor
escape from the host immune system. Major gaps in knowledge that impede the …

Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …

Ecto-5′-nucleotidase [cluster of differentiation 73 (CD73)] is a ubiquitously expressed
glycosylphosphatidylinositol-anchored glycoprotein that converts extracellular adenosine …

Over 200 million individuals worldwide are estimated to have peripheral artery disease
(PAD). Although the term peripheral can refer to any outer branch of the vasculature, the …

CD73, a cell surface 5′ nucleotidase that generates adenosine, has emerged as an
attractive therapeutic target for reprogramming cancer cells and the tumor microenvironment …

Background Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are
effective substrates for NAD synthesis, which may act as vasoprotective agents. Here, we …

Background During myocardial damage, the sex hormone estrogen and CD73, the main
enzyme that converts AMP into adenosine, are cardioprotective molecules. However, it is …

Extracellular vesicles (EVs) released by a variety of cell types have been shown to act as a
natural delivery system for bioactive molecules such as RNAs and proteins. EV therapy …