Emerging computational methods in mass spectrometry imaging

H Hu, J Laskin - Advanced Science, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of
hundreds of molecules in biological samples with high sensitivity and molecular specificity …

Spatially aware dimension reduction for spatial transcriptomics

L Shang, X Zhou - Nature communications, 2022 - nature.com
Spatial transcriptomics are a collection of genomic technologies that have enabled
transcriptomic profiling on tissues with spatial localization information. Analyzing spatial …

Benchmarking spatial clustering methods with spatially resolved transcriptomics data

Z Yuan, F Zhao, S Lin, Y Zhao, J Yao, Y Cui… - Nature …, 2024 - nature.com
Spatial clustering, which shares an analogy with single-cell clustering, has expanded the
scope of tissue physiology studies from cell-centroid to structure-centroid with spatially …

Recent advances in mass spectrometry imaging combined with artificial intelligence for spatially clarifying molecular profiles: Toward biomedical applications

H Zhang, J Zhang, C Yuan, D Zhang, D Lu… - TrAC Trends in …, 2024 - Elsevier
Mass spectrometry imaging (MSI) is an intuitive and multidimensional analysis method that
provides spatial information on molecules in tissues or cells; it is widely used in biomedical …

Spatially resolved metabolomics and lipidomics reveal salinity and drought-tolerant mechanisms of cottonseeds

B Liu, X Wang, K Li, Z Cai - Journal of agricultural and food …, 2021 - ACS Publications
In the current era of global climate change, environmental stresses, especially drought and
salt, have impaired the growth and productivity of crops, eg, cotton. Understanding the …

iSegMSI: an interactive strategy to improve spatial segmentation of mass spectrometry imaging data

L Guo, X Liu, C Zhao, Z Hu, X Xu, KK Cheng… - Analytical …, 2022 - ACS Publications
Spatial segmentation is a critical procedure in mass spectrometry imaging (MSI)-based
biochemical analysis. However, the commonly used unsupervised MSI segmentation …

基质辅助激光解吸电离-质谱成像技术(MALDI-MSI) 及其在脑神经性疾病研究中的应用

金涛, 潘本松, 聂洪港 - 计量科学与技术, 2022 - jlkj.nim.ac.cn
大脑是人体内结构最精细, 功能最复杂的高级器官, 其化学物质种类众多, 功能多样,
作用机制复杂. 研究证明, 脑中枢神经系统疾病的病变脑组织都涉及到一些神经分子的改变 …

Metabolic perturbation score-based mass spectrometry imaging spatially resolves a functional metabolic response

X Song, Q Zang, J Zhang, S Gao, K Zheng… - Analytical …, 2023 - ACS Publications
Metabolic perturbation score-based mass spectrometry imaging (MPS-MSI) is proposed to
reveal the spatially resolved functional metabolic response associated with disease …

Modern machine‐learning applications in ambient ionization mass spectrometry

AA Sorokin, SI Pekov, DS Zavorotnyuk… - Mass Spectrometry …, 2025 - Wiley Online Library
This article provides a comprehensive overview of the applications of methods of machine
learning (ML) and artificial intelligence (AI) in ambient ionization mass spectrometry (AIMS) …

Advances in mass spectrometry imaging for toxicological analysis and safety evaluation of pharmaceuticals

Y Chen, Y Xie, L Li, Z Wang… - Mass Spectrometry …, 2023 - Wiley Online Library
Safety issues caused by pharmaceuticals have frequently occurred worldwide, posing a
tremendous threat to human health. As an essential part of drug development, the …