Since the lipid profile is altered by physical activity, the study of lipid metabolism is a
remarkable element in understanding if and how physical activity affects the health of both …

Our understanding of adipose tissue biology has progressed rapidly since the turn of the
century. White adipose tissue has emerged as a key determinant of healthy metabolism and …

Background—The failing human heart is characterized by metabolic abnormalities, but
these defects remains incompletely understood. In animal models of heart failure there is a …

The ability of mammals to resist body fat accumulation is linked to their ability to expand the
number and activity of “brown adipocytes” within white fat depots. Activation of β-adrenergic …

With nonalcoholic steatohepatitis (NASH), NASH cirrhosis, and NASH-related hepatocellular
carcinoma becoming increasingly prevalent, the need for effective therapies has never been …

Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs)
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

Triacylglycerol (TAG) stored in adipose tissue (AT) can be rapidly mobilized by the hydrolytic
action of the three main lipases of the adipocyte. The non-esterified fatty acids (NEFA) …

Beige or brite (brown-in-white) adipocytes are present in white adipose tissue (WAT) and
have a white fat-like phenotype that when stimulated acquires a brown fat-like phenotype …

The role of brown adipose tissue in the regulation of energy balance and maintenance of
body weight is well known in rodents. Recently, interest in this tissue has re-emerged due to …