Objective: Discuss evidence referring to the genetic role in congenital heart diseases,
whether chromosomic alterations or monogenic diseases. Data source: LILACS, PubMed …

Key message Synthetic control systems have led to significant advancement in the study
and engineering of unicellular organisms, but it has been challenging to apply these tools to …

Clinical presentation of congenital heart disease is heterogeneous, making identification of
the disease-causing genes and their genetic pathways and mechanisms of action …

Background: Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged
as a promising strategy to remuscularize injured myocardium. However, it is insufficient to …

Tbx20 is a member of the Tbx1 subfamily of T-box-containing genes and is known to play a
variety of fundamental roles in cardiovascular development and homeostasis as well as …

Background: The pathogenic missense variant p. G125R in TBX5 (T-box transcription factor
5) causes Holt–Oram syndrome (also known as hand–heart syndrome) and early onset of …

Rationale: Dextro-transposition of the great arteries (D-TGA) is a severe congenital heart
defect which affects approximately 1 in 4,000 live births. While there are several reports of D …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

During embryonic development, the cardiovascular system and the central nervous system
exhibit a coordinated developmental process through intricate interactions. Congenital heart …

Rationale: There is growing evidence that common variants and rare sequence alterations
in regulatory sequences can result in birth defects or predisposition to disease. Congenital …