Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

With the rapid expansion of the obesity epidemic, nonalcoholic fatty liver disease is now the
most common chronic liver disease, with almost 25% global prevalence. Nonalcoholic fatty …

The liver is not only the main metabolic site of exogenous compounds and drugs, but also
an important immune organ in the human body. When a large number of nonself substances …

Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …

Abstract Background and Aims Although NASH can lead to severe clinical consequences,
including cirrhosis and hepatocellular carcinoma, no effective treatment is currently …

Nutraceuticals which are abundant in foods have attracted much attention due to their
bioactive activities of anti-obesity, anti-hyperlipidemia and anti-atherosclerosis …

Rationale: Macrophages play multi-dimensional roles in hepatic fibrosis. Studies have
implicated Notch signaling mediated by the transcription factor RBP-J in macrophage …

Background & Aims The hepatocyte Notch pathway is a pathogenic factor in non-alcoholic
steatohepatitis (NASH)-associated fibrosis, but its role in hepatocellular carcinoma (HCC) is …

The epidemic of obesity is a serious public health problem. In this study, the effect of
theabrownin from dark tea on obesity was evaluated by biochemical tests and nuclear …

Epidemiological evidence showed that patients suffering from obesity and T2DM are
significantly at higher risk for chronic low-grade inflammation, oxidative stress, nonalcoholic …