The transcriptional program, functional heterogeneity, and clinical targeting of mast cells
Mast cells are unique tissue-resident immune cells that express an array of receptors that
can be activated by several extracellular cues, including antigen–immunoglobulin E (IgE) …
can be activated by several extracellular cues, including antigen–immunoglobulin E (IgE) …
Advanced phenotyping in hypersensitivity drug reactions to NSAID s
P Ayuso, N Blanca‐López, I Doña… - Clinical & …, 2013 - Wiley Online Library
Non‐steroidal anti‐inflammatory drugs (NSAID s) are the medications most frequently
involved in hypersensitivity drug reactions. Because NSAID s are prescribed for many …
involved in hypersensitivity drug reactions. Because NSAID s are prescribed for many …
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
Background In order to identify novel loci associated with Alzheimer's disease (AD), we
conducted a genome-wide association study (GWAS) in the Spanish population. Methods …
conducted a genome-wide association study (GWAS) in the Spanish population. Methods …
Significant association of FcɛRIα promoter polymorphisms with aspirin-intolerant chronic urticaria
BACKGROUND: Although the mechanism that underlies aspirin hypersensitivity is not
completely understood, an IgE-mediated response was reported for a patient with aspirin …
completely understood, an IgE-mediated response was reported for a patient with aspirin …
Biochemical pathogenesis of aspirin exacerbated respiratory disease (AERD)
A Narayanankutty, JM Reséndiz-Hernández… - Clinical …, 2013 - Elsevier
Aspirin exacerbated respiratory disease (AERD) is a distinct clinical entity characterized by
eosinophilic rhinosinusitis, asthma and often nasal polyposis. Exposure to aspirin or other …
eosinophilic rhinosinusitis, asthma and often nasal polyposis. Exposure to aspirin or other …
Human FcR polymorphism and disease
X Li, AW Gibson, RP Kimberly - Fc Receptors, 2014 - Springer
Fc receptors play a central role in maintaining the homeostatic balance in the immune
system. Our knowledge of the structure and function of these receptors and their naturally …
system. Our knowledge of the structure and function of these receptors and their naturally …
Unraveling the genetic basis of aspirin hypersensitivity in asthma beyond arachidonate pathways
SM Park, JS Park, HS Park… - Allergy, Asthma & …, 2013 - synapse.koreamed.org
Although aspirin-exacerbated respiratory disease (AERD) has attracted a great deal of
attention because of its association with severe asthma, it remains widely under-diagnosed …
attention because of its association with severe asthma, it remains widely under-diagnosed …
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells
G Cruse, MA Beaven, I Ashmole, P Bradding… - Immunity, 2013 - cell.com
Human linkage analyses have implicated the MS4A2-containing gene locus (encoding
FcεRIβ) as a candidate for allergy susceptibility. We have identified a truncation of FcεRIβ (t …
FcεRIβ) as a candidate for allergy susceptibility. We have identified a truncation of FcεRIβ (t …
Regulation of trafficking and signaling of the high affinity IgE receptor by FcεRIβ and the potential impact of FcεRIβ splicing in allergic inflammation
GK Arthur, G Cruse - International Journal of Molecular Sciences, 2022 - mdpi.com
Mast cells are tissue-resident immune cells that function in both innate and adaptive
immunity through the release of both preformed granule-stored mediators, and newly …
immunity through the release of both preformed granule-stored mediators, and newly …
[PDF][PDF] Update on recent advances in the management of aspirin exacerbated respiratory disease
NS Palikhe, JH Kim, HS Park - Yonsei medical journal, 2009 - synapse.koreamed.org
Aspirin intolerant asthma (AIA) is frequently characterized as an aspirin (ASA)-exacerbated
respiratory disease (AERD). It is a clinical syndrome associated with chronic severe …
respiratory disease (AERD). It is a clinical syndrome associated with chronic severe …