Lyme borreliosis

AC Steere, F Strle, GP Wormser, LT Hu… - Nature reviews Disease …, 2016 - nature.com
Lyme borreliosis is a tick-borne disease that predominantly occurs in temperate regions of
the northern hemisphere and is primarily caused by the bacterium Borrelia burgdorferi in …

SOCS proteins as regulators of inflammatory responses induced by bacterial infections: a review

SA Duncan, DR Baganizi, R Sahu, SR Singh… - Frontiers in …, 2017 - frontiersin.org
Severe bacterial infections can lead to both acute and chronic inflammatory conditions.
Innate immunity is the first defense mechanism employed against invading bacterial …

Association of a Toll‐like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic‐refractory Lyme arthritis

K Strle, JJ Shin, LJ Glickstein… - Arthritis & Rheumatism, 2012 - Wiley Online Library
Abstract Objective Single‐nucleotide polymorphisms (SNPs) that alter immune function,
inflammatory responses, and disease susceptibility have been identified in several genes …

Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection

N Gratz, H Hartweger, U Matt, F Kratochvill… - PLoS …, 2011 - journals.plos.org
Streptococcus pyogenes is a Gram-positive human pathogen that is recognized by yet
unknown pattern recognition receptors (PRRs). Engagement of these receptor molecules …

The danger signal S100B integrates pathogen–and danger–sensing pathways to restrain inflammation

G Sorci, G Giovannini, F Riuzzi, P Bonifazi… - PLoS …, 2011 - journals.plos.org
Humans inhale hundreds of Aspergillus conidia without adverse consequences. Powerful
protective mechanisms may ensure prompt control of the pathogen and inflammation. Here …

Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids

W Wang, N Lv, S Zhang, G Shui, H Qian, J Zhang… - Nature medicine, 2012 - nature.com
Adequate lipid secretion by mammary glands during lactation is essential for the survival of
mammalian offspring. However, the mechanism governing this process is poorly …

CD 14 is a key organizer of microglial responses to CNS infection and injury

H Janova, C Böttcher, IR Holtman, T Regen… - Glia, 2016 - Wiley Online Library
Microglia, innate immune cells of the CNS, sense infection and damage through overlapping
receptor sets. Toll‐like receptor (TLR) 4 recognizes bacterial lipopolysaccharide (LPS) and …

Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu

EG Reed-Geaghan, QW Reed, PE Cramer… - Journal of …, 2010 - Soc Neuroscience
Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ)-containing
plaques within the brain that is accompanied by a robust microglial-mediated inflammatory …

Dietary‐resistant starch improves maternal glycemic control in Goto–Kakizaki rat

L Shen, MJ Keenan, A Raggio… - Molecular nutrition & …, 2011 - Wiley Online Library
Scope: Dietary prebiotics show potential in anti‐diabetes. Dietary resistant starch (RS) has a
favorable impact on gut hormone profiles, including glucagon‐like peptide‐1 (GLP‐1) …

SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells

QY Sun, LW Ding, K Johnson, S Zhou, JW Tyner… - Oncogene, 2019 - nature.com
Apoptosis of cancer cells occurs by a complex gene regulatory network. Here we showed
that SOX7 was significantly downregulated in different cancer types, especially in lung and …