The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …

The familial forms of non-medullary thyroid carcinoma (FNMTC) represent approximately 5%
of thyroid neoplasms. Nine FNMTC susceptibility loci have been mapped; however, only the …

Objective FOXE 1 is a transcription factor required for thyroid differentiation and function.
FOXE1 locus polymorphisms (chromosome 9q22. 33) were recently associated with …

A dramatic increase in the incidence of papillary thyroid carcinoma (PTC) after childhood
exposure to ionizing radiation from the Chernobyl nuclear accident has been described as …

Context: Polyalanine tract variations in transcription factors have been identified for a wide
spectrum of developmental disorders. The thyroid transcription factor forkhead factor E1 …

Context Foxe1 is a key thyroid developmental transcription factor. Germline deletion results
in athyreosis and congenital hypothyroidism. Some data suggest an ongoing role for …

Several single-nucleotide polymorphisms (SNPs) have been associated with papillary and
follicular thyroid cancer (PTC and FTC, respectively) risk, but few have replicated. After …

Background: Single nucleotide polymorphisms (SNPs) near thyroid transcription factor
genes (FOXE1 rs965513/NKX2-1 rs944289) have been shown to be associated with …

Polyglutamine (polyGln) expansions in nine human proteins result in neurological diseases
and induce the proteins' tendency to form β-rich amyloid fibrils and intracellular deposits …

Thyroid cancer is the most common endocrine malignancy and nonmedullary thyroid
carcinoma (NMTC) represents 90% of all cases. NMTC risk in first‐degree relatives of …