The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Alzheimer's disease (AD) is the major cause of dementia, characterized by the presence of
amyloid-beta plaques and neurofibrillary tau tangles. Plaques and tangles are associated …

There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …

Quantification and detection of the hierarchical organization of behavior is a major challenge
in neuroscience. Recent advances in markerless pose estimation enable the visualization of …

Background: The fornix is the primary axonal tract of the hippocampus, connecting it to
modulatory subcortical structures. This review reveals that fornix damage causes cognitive …

Neuronal network dysfunction is a hallmark of Alzheimer's disease (AD). However, the
underlying pathomechanisms remain unknown. We analyzed the hippocampal …

Progressive cognitive decline in Alzheimer's disease could either be caused by a spreading
molecular pathology or by an initially focal pathology that causes aberrant neuronal activity …

Despite the development of multiple pharmacological approaches over the years aimed at
treating Alzheimer's Disease (AD) only very few have been approved for clinical use in …

Among the central features of Alzheimer's disease (AD) progression are altered levels of the
neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST …

This paper aims to explain and expand the dynamic mechanisms underlying the interesting
but controversial experimental phenomena in the optogenetic regulation of Alzheimer's …