In recent times, there has been a growing interest in artificial neural networks, which are a
rough simulation of the information processing ability of the human brain, as modern and …

Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been
declared a global pandemic and urgent treatment and prevention strategies are needed …

With the dawn of new century, major technological advances in the drug discovery field have
revolutionized absorption, distribution, metabolism, excretion and toxicity (ADME/T) profiling …

We compare three different approaches to scale clearance (CL) from human hepatocyte and
microsome CLint (intrinsic CL) for 52 drug compounds. By using the well-stirred model with …

Systematic under-prediction of clearance is frequently associated with in vitro kinetic data
when extrapolated using physiological scaling factors, appropriate binding parameters and …

Objective This study aimed to assess the pharmacokinetic (PK) interactions of anaprazole,
clarithromycin, and amoxicillin using physiologically based pharmacokinetic (PBPK) models …

Despite their importance in determining the dosing regimen of drugs in the clinic, only a few
studies have investigated methods for predicting blood-to-plasma concentration ratios (Rb) …

Accurate prediction of human pharmacokinetics using in vitro tools is an important task
during drug development. Albeit, currently used in vitro systems for clearance extrapolation …

Objectives To investigate if dried blood spots could be used for therapeutic drug monitoring
of the antiepileptic drugs, carbamazepine, lamotrigine and valproic acid in children with …

Estimates of the human oral absolute bioavailability were made by using a physiological-
based pharmacokinetic model of absorption and the drug solubility at the gastrointestinal pH …