In today's modern era of medicine, macromolecular compounds such as proteins, peptides
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …

The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

Twenty years ago, the discovery of peptides able to cross cellular membranes launched a
novel field in molecular delivery based on these non-invasive vectors, most commonly …

More than 40 nanomedicines are already in routine clinical use with a growing number
following in preclinical and clinical development. The therapeutic objectives are often …

Peptides are versatile and attractive biomolecules that can be applied to modulate genetic
mechanisms like alternative splicing. In this process, a single transcript yields different …

Cell‐penetrating peptides, such as antibodies, have gained great attention as tools for the
development of specific delivery systems for payloads, which might be applied as non …

Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Antimicrobial peptides (AMPs) are short oligopeptides that can penetrate the bacterial inner
and outer membranes. Together with cell-penetrating peptides (CPPs), they are called …

MtDef4 is a 47-amino acid cysteine-rich evolutionary conserved defensin from a model
legume Medicago truncatula. It is an apoplast-localized plant defense protein that inhibits …

Trp is unique among the amino acids since it is involved in many different types of
noncovalent interactions such as electrostatic and hydrophobic ones, but also in π-π, π …