Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

Although patients with microsatellite instable metastatic colorectal cancer (CRC) benefit from
immune checkpoint blockade, chemotherapy with targeted therapies remains the only …

An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify
combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4) …

Fibroblasts have a considerable functional and molecular heterogeneity and can play
various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL …

In colorectal cancers, the tumor microenvironment plays a key role in prognosis and therapy
efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical …

T memory stem cells (T SCM) display increased self-renewal and prolonged survival
capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell …

The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has
prevailed throughout the past decade. However, recent high-throughput, high-resolution …

Tumor-associated inflammation (TAI) is a feature of essentially all cancers and can confer
both tumor-promoting and-suppressive functions. Cancer-associated fibroblasts (CAF) …