The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

Each heartbeat is initiated by the action potential, an electrical signal that depolarizes the
plasma membrane and activates a cycle of calcium influx via voltage-gated calcium …

Cardiac hypertrophy is a leading predicator of progressive heart disease that often leads to
heart failure and a loss of cardiac contractile performance associated with profound …

Recombinant adenoviruses were used to overexpress green fluorescent protein (GFP)‐
fused auxiliary Ca2+ channel β subunits (β1‐β4) in cultured adult rat heart cells, to explore …

Transient elevations of intracellular Ca2+ play a signalling role in such complex cellular
functions as contraction, secretion, fertilization, proliferation, metabolism, heartbeat and …

GY Oudit, Z. Kassiri, R. Sah, RJ Ramirez, C. Zobel and PH Backx. The Molecular Physiology
of the Cardiac Transient Outward Potassium Current (Ito) in Normal and Diseased …

Gender has recently been implicated as an important modulator of cardiovascular disease.
However, it is not known how gender may specifically influence the Ca2+-handling deficits …

Background—Cardiac hypertrophy underlies arrhythmias and sudden death, for which
mineralocorticoid receptor (MR) activity has recently been implicated. We sought to establish …

Background—Calcium imbalances have been implicated as an underlying mechanism of
human cardiac dysfunction. The voltage-dependent calcium channel plays a critical role in …

Ca2+ channel β-subunit interactions with pore-forming α-subunits are long-thought to be
obligatory for channel trafficking to the cell surface and for tuning of basal biophysical …