In cells, genes are transcribed into mRNAs, and the latter are translated into proteins. Due to
the feedbacks between these processes, the kinetics of gene expression may be complex …

To maintain a stable intracellular environment, cells utilize complex and specialized defense
systems against a variety of external perturbations, such as electrophilic stress, heat shock …

It has often been taken for granted that negative feedback loops in gene regulation work as
homeostatic control mechanisms. If one increases the regulation strength a less noisy signal …

Normal development of multicellular organisms requires cells to respond properly according
to their positions. Positional information is often provided to cells as concentrations of …

Biological networks have evolved through adaptation in uncertain environments. Of the
different possible design paradigms, some may offer functional advantages over others …

Small non-coding RNA (sRNA) plays very important role in the post transcriptional
regulation in various organisms. In complex regulatory networks, highly significant relative …

Understanding the information processing ability of signal transduction pathways is of great
importance because of their crucial roles in triggering various cellular responses. Despite …

We present a model to describe the on-off switching of transcriptional activity in a genetic
assembly by considering the intrinsic characteristics of a giant genomic DNA molecule …

Mutational robustness of gene regulatory networks refers to their ability to generate constant
biological output upon mutations that change network structure. Such networks contain …

The feedback between mRNA and regulatory-protein production may result in bistability of
gene transcription. If the mRNA and/or protein number are low, one can observe …