The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …

Nonalcoholic fatty liver disease (NAFLD) is an increasing global public health burden.
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …

The mechanisms that drive nonalcoholic fatty liver disease (NAFLD) remain incompletely
understood. This large multicenter study characterized the transcriptional changes that occur …

Metabolic associated fatty liver disease (MAFLD) encompasses a broad spectrum of hepatic
disorders, including steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis. We …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the commonest cause
of chronic liver disease worldwide and represents an unmet precision medicine challenge …

Obesity and liver diseases are associated with the disruption of the circadian clock that
orchestrates mammalian physiology to optimize nutrient metabolism and storage. Here, we …

The incidence of hepatocellular carcinoma (HCC) is rapidly rising largely because of
increased obesity leading to nonalcoholic steatohepatitis (NASH), a known HCC risk factor …

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy
approved. A major hurdle in NASH drug development is the poor translatability of preclinical …

Background and Aims NAFLD is the most common liver disease worldwide. NASH, the
progressive form of NAFLD, and advanced fibrosis are associated with poor outcomes. We …

Fibrosis is characterized by the excessive production of collagen and other extracellular
matrix (ECM) components and represents a leading cause of morbidity and mortality …