PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …

The polo-like kinase 1 (PLK1) acts in concert with cyclin-dependent kinase 1–cyclin B1 and
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …

Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis
and cytokinesis. In agreement with a broad range of proposed functions during cell division …

The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in
other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division,. By contrast …

Fine-mapping of the cell-division cycle, notably the identification of mitotic kinase signaling
pathways, provides novel opportunities for cancer-drug discovery. As a key regulator of …

Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of
genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in …

We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces
centrosome amplification through the simultaneous generation of multiple procentrioles …

Mammalian polo-like kinase 1 (Plk1) is structurally related to the polo gene product of
Drosophila melanogaster, Cdc5p of Saccharomyces cerevisiae, and plo1+ of …

Summary Polo-like kinase 4 (Plk4) is a key regulator of centriole duplication, but the
mechanism underlying its recruitment to mammalian centrioles is not understood. In flies …

Mammalian polo-like kinases (Plks) are characterized by the presence of an N-terminal
protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate …