Electrochemical transformations catalyzed by cytochrome P450s and peroxidases
Cytochrome P450s (Cyt P450s) and peroxidases are enzymes featuring iron heme cofactors
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations
R Bernhardt, VB Urlacher - Applied microbiology and biotechnology, 2014 - Springer
Cytochromes P450 (CYPs) belong to the superfamily of heme b containing
monooxygenases with currently more than 21,000 members. These enzymes accept a vast …
monooxygenases with currently more than 21,000 members. These enzymes accept a vast …
From electrochemistry to enzyme kinetics of cytochrome P450
VV Shumyantseva, AV Kuzikov, RA Masamrekh… - Biosensors and …, 2018 - Elsevier
This review is an attempt to describe advancements in the electrochemistry of cytochrome
P450 enzymes (EC 1.14. 14.1) and to study molecular aspects and catalytic behavior of …
P450 enzymes (EC 1.14. 14.1) and to study molecular aspects and catalytic behavior of …
Optimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolites
G Di Nardo, G Gilardi - International Journal of Molecular Sciences, 2012 - mdpi.com
Drug metabolism in human liver is a process involving many different enzymes. Among
them, a number of cytochromes P450 isoforms catalyze the oxidation of most of the drugs …
them, a number of cytochromes P450 isoforms catalyze the oxidation of most of the drugs …
Improving the efficiency of electrocatalysis of cytochrome P450 3A4 by modifying the electrode with membrane protein streptolysin O for studying the metabolic …
PI Koroleva, AA Gilep, SV Kraevsky, TV Tsybruk… - Biosensors, 2023 - mdpi.com
In the present work, screen-printed electrodes (SPE) modified with a synthetic surfactant,
didodecyldimethylammonium bromide (DDAB) and streptolysin O (SLO) were prepared for …
didodecyldimethylammonium bromide (DDAB) and streptolysin O (SLO) were prepared for …
Approaches for increasing the electrocatalitic efficiency of cytochrome P450 3A4
VV Shumyantseva, PI Koroleva, TV Bulko, TV Shkel… - …, 2023 - Elsevier
The electrochemically driven cytochrome P450 reactions have great promise as drug
sensing device, new drug searching tool and bioreactor with broad synthetic application. In …
sensing device, new drug searching tool and bioreactor with broad synthetic application. In …
Chimeric P 450 enzymes: Activity of artificial redox fusions driven by different reductases for biotechnological applications
SJ Sadeghi, G Gilardi - Biotechnology and Applied …, 2013 - Wiley Online Library
This review covers the current state of knowledge regarding artificial fusion constructs of
cytochrome P 450 enzymes in which the activity of the catalytic heme is driven by reductases …
cytochrome P 450 enzymes in which the activity of the catalytic heme is driven by reductases …
Protein electrochemistry: application in medicine. A review
EV Suprun, VV Shumyantseva, AI Archakov - Electrochimica Acta, 2014 - Elsevier
This mini-review outlines the current state of knowledge in field of protein electrochemistry
and its application in medicine. Protein electrochemistry is considered according to (i) its …
and its application in medicine. Protein electrochemistry is considered according to (i) its …
Rapid multichannel fluorescent probe assay for CYP450 inhibition screening and drug interaction monitoring
Y Song, J Zeng, J Long, A Wang, K Chen, D Yan - Microchemical Journal, 2024 - Elsevier
Abstract Cytochrome P450 (CYP450) inhibition induced drug interactions (DDIs) are a
primary cause of adverse drug reactions (ADRs). The rapid identification of CYP450 …
primary cause of adverse drug reactions (ADRs). The rapid identification of CYP450 …
Current approaches for investigating and predicting cytochrome P450 3A4-ligand interactions
IF Sevrioukova, TL Poulos - Monooxygenase, peroxidase and …, 2015 - Springer
Abstract Cytochrome P450 3A4 (CYP3A4) is the major and most important drug-
metabolizing enzyme in humans that oxidizes and clears over a half of all administered …
metabolizing enzyme in humans that oxidizes and clears over a half of all administered …