• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The microbiology, epidemiology, diagnostics, and treatment of infective endocarditis (IE)
have changed significantly since the Duke Criteria were published in 1994 and modified in …

Valvular heart disease (VHD) is a major contributor to loss of physical function, quality of life
and longevity. The epidemiology of VHD varies substantially around the world, with a …

Valvular heart disease is a rapidly growing cause of global cardiovascular morbidity and
mortality with diverse and evolving geographic distribution. The prevalence of rheumatic …

This document on cardiovascular infection, including infective endocarditis, is the first in the
American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the …

Key Clinical Points Native-Valve Infective Endocarditis The modified Duke criteria, which are
based on findings on physical examination, echocardiography, microbiologic studies, and …

Infections have become the major cause of morbidity and mortality among patients with
chronic lymphocytic leukemia (CLL) due to immune dysfunction and cytotoxic CLL treatment …

Infective endocarditis in children is a rare entity that poses multiple challenges. A history of
congenital heart disease is the most common risk factor, although in recent years, other …

Whipple's disease is a chronic and systemic disease caused by the Gram-positive bacterium
Tropheryma whipplei that primarily affects the gastrointestinal tract. Data from the last two …

Infective endocarditis is a life-threatening disease of the endocardium of the heart and
cardiac valves, caused by several infectious agents, ranging from Streptococci to rickettsia. It …