A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

[HTML][HTML] Nanomechanical mapping of soft materials with the atomic force microscope: methods, theory and applications

R Garcia - Chemical Society Reviews, 2020 - pubs.rsc.org
Fast, high-resolution, non-destructive and quantitative characterization methods are needed
to develop materials with tailored properties at the nanoscale or to understand the …

Hydrogel‐based 3D bioprinting for bone and cartilage tissue engineering

P Abdollahiyan, F Oroojalian… - Biotechnology …, 2020 - Wiley Online Library
As a milestone in soft and hard tissue engineering, a precise control over the micropatterns
of scaffolds has lightened new opportunities for the recapitulation of native body organs …

Role of mitochondria in physiology of chondrocytes and diseases of osteoarthritis and rheumatoid arthritis

S Kan, M Duan, Y Liu, C Wang, J Xie - Cartilage, 2021 - journals.sagepub.com
Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …

[HTML][HTML] Mechanical cues: bidirectional reciprocity in the extracellular matrix drives mechano-signalling in articular cartilage

SJ Gilbert, CS Bonnet, EJ Blain - International journal of molecular …, 2021 - mdpi.com
The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …

Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis

DR Chery, B Han, Q Li, Y Zhou, SJ Heo, B Kwok… - Acta biomaterialia, 2020 - Elsevier
The pericellular matrix (PCM) of cartilage is a structurally distinctive microdomain
surrounding each chondrocyte, and is pivotal to cell homeostasis and cell-matrix interactions …

[HTML][HTML] An evidence-based systematic review of human knee post-traumatic osteoarthritis (PTOA): timeline of clinical presentation and disease markers, comparison …

CM Khella, R Asgarian, JM Horvath, B Rolauffs… - International Journal of …, 2021 - mdpi.com
Understanding the causality of the post-traumatic osteoarthritis (PTOA) disease process of
the knee joint is important for diagnosing early disease and developing new and effective …

[HTML][HTML] Proteoglycans in articular cartilage and their contribution to chondral injury and repair mechanisms

L Alcaide-Ruggiero, R Cugat… - International Journal of …, 2023 - mdpi.com
Proteoglycans are vital components of the extracellular matrix in articular cartilage, providing
biomechanical properties crucial for its proper functioning. They are key players in chondral …

Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus

C Wang, BK Brisson, M Terajima, Q Li, B Han… - Matrix Biology, 2020 - Elsevier
Despite the fact that type III collagen is the second most abundant collagen type in the body,
its contribution to the physiologic maintenance and repair of skeletal tissues remains poorly …

[HTML][HTML] The extracellular matrix of articular cartilage controls the bioavailability of pericellular matrix-bound growth factors to drive tissue homeostasis and repair

TL Vincent, O McClurg, L Troeberg - International Journal of Molecular …, 2022 - mdpi.com
The extracellular matrix (ECM) has long been regarded as a packing material; supporting
cells within the tissue and providing tensile strength and protection from mechanical stress …